Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-237-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Sediment toxicity
Administrative data
Link to relevant study record(s)
- Endpoint:
- sediment toxicity: long-term
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Reference
Description of key information
In accordance with Column 2 of REACH Annex IX the study does not need to be conducted.
Key value for chemical safety assessment
Additional information
Testing for sediment toxicity is not considered necessary because:
- PNECsediment has been calculated from PNECfreshwater on the basis of the equilibrium partitioning method; the risk characterisation ratios (RCR) based on PNECsediment derived from this method are <1.
Considerations for applicability of the Equilibrium Partitioning to chelating substances:
Taken from ECHA (2008, R.10.5.2.1) “In the partitioning method, it is assumed that the:
• sediment-dwelling organisms and water column organisms are equally sensitive to the chemical;
• concentration of the substance in sediment, interstitial water and benthic organisms are at thermodynamic equilibrium: the concentration in any of these phases can be predicted using the appropriate partition coefficients;
• sediment/water partition coefficients can either be measured or derived on the basis of a generic partition method from separately measurable characteristics of the sediment and the properties of the chemical (for the derivation of the sediment-water partition coefficient and the limits of the calculation methods see Section R.16.4.3.3).”
Based on the aquatic toxicity data available, including read-across data, there is no indication that the first assumption does not hold true for the substances in the HEDP category.
The concentration of the substance in sediment, interstitial water and benthic organisms can be predicted using appropriate coefficients. For the derivation of equilibrium partitioning sediment PNECs the Kp(susp-water)= 2000 l/kg, equivalent to K(susp-water)of 500 m3/m3have been derived from available experimental evidence, consistent with adsorption behaviour of other phosphonate complexing agents. The use of substance specific measured adsorption values result in partition coefficient that take into account the inorganic substrate chelating properties of phosphonates, i.e. the resulting partition coefficient values are higher than if they had been calculated based on a true Koc or Kow.
An important factor when conducting the risk assessment of phosphonate substances to sediment (and soil) organisms is their bioavailability in these substrates. The substances are considered to be virtually unavailable due to their strong chelating potential. The equilibrium is strongly in favour of the bound form, as discussed in the adsorption/desorption section, such that the adsorption is considered effectively irreversible. As such, the concentration in interstitial water using this method represents a maximum value.
- Using the relationships that Cs/Cw = Kdat equilibrium, and when total loading rate = Cs*Ms+Cw*Mwat equilibrium (also expressed by Equation R.16-7 in ECHA guidance: Kcomp-water= Ctotal.comp/Cporewater.comp= Fair.comp*Kair-water+ Fwater.comp+ Fsolid.comp*(Kp.comp/1000)*RHOsolid) the distribution of HEDP may be modelled. Using this method, it can be seen that a nominal 100 mg HEDP/kg wwt in a standard sediment with the compositional characteristics defined in ECHA guidance part R.16 and relevant OECD testing guidelines (e.g. OECD TG 233) is equivalent to a concentration of approximately 0.1 mg/l concentration in the sediment interstitial/overlying water. Similarly, in a typical soil a nominal 100 mg HEDP/kg wwt would be equivalent to a concentration of approximately 0.1 mg/l in the soil interstitial water.
- Additionally, based on local exposure concentrations in the exposure assessment of the HEDP Category, PECs in the range 1E-10 to 1E-02 mg/l in soil interstitial water and in the range 1– 60 mg/kg wet weight sediment (equivalent to 0.05 – 0.3 mg/l in sediment interstitial water) are predicted by EUSES. Aquatic testing does not suggest that effects are expected to be observed at these concentrations. The lowest NOEC in long-term aquatic testing is 6.75 mg/l as HEDP (acid equivalent). The PNECfresh watervalue is 0.14 mg/l.
- The adsorption value of HEDP to inorganic substrate is considered to be as strong as EDTA (CAS 60-00-4, Risk Assessment 2004)a known complexing agent, which is considered to be non-toxic and to reduce bioavailability of metals and has been considered as a remediation process.
- Different feeding patterns will amount to different exposures.Lumbriculus variegatusandTubifex tubifexfeed through ingestion of sediment particles, and therefore will be more susceptible to exposure of phosphonate bound to the inorganic matter; while organisms such as theChironomus spp.feed on organic matter therefore exposure is likely to be very limited.
- The adsorption of chemicals from the gut of sediment invertebrates is mediated through the presence of amino acids and surfactants at near neutral pHs (National Research Council, 2003), which will not dissociate the phosphonates from the inorganic substrate. Therefore phosphonates are not expected to become more bioavailable to sediment-ingesting organisms.
Based on the above information, substances will be very minimally bioavailable to sediment organisms, due to the substances’ substrate binding capacity; hence the Equilibrium partitioning model may be overestimating toxicity. Therefore, the use of Equilibrium partitioning is considered to be a conservative approach, when the coefficients are calculated based on measured Kddata.
References:
National Research Council, 2003, Bioavailability of Contaminants in Soils and Sediments: Processes, Tools, and Applications Committee on Bioavailability of Contaminants in Soils and Sediments, National Research Council
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
