3-acetoxymethylen-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Oxidising properties

Link to relevant study record(s)

Reference

Endpoint:

oxidising solids

Type of information:

experimental study

Adequacy of study:

key study

Study period:

September 25, 2012 to November 02, 2012

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Comparable to guideline study (Regulation EC No. 440/2008 Method A.17.) with acceptable restrictions

Qualifier:

according to guideline

Guideline:

EU Method A.17 (Oxidising Properties (Solids))

Deviations:

no

GLP compliance:

no

Contact with:

powdered cellulose

Sample tested:

other: barium nitrate:cellulose (60:40 %)

Remarks:

migrated information

Parameter:

maximum burning rate

Result:

1.18 mm/s

Key result

Sample tested:

test mixture as specified

Remarks:

test item : cellulose (5:95 %)

Parameter:

maximum burning rate

Result:

0.96 mm/s

The burning rates for the mixtures of barium nitrate with cellulose are shown inTable1.

Table1: Burning rates for the mixtures of barium nitrate with cellulose

Mixtures of barium nitrate : cellulose	Burning time	Burning rate
50 : 50 % (w/w)	207 s	0.97 mm/s
55 : 45 % (w/w)	172 s	1.16 mm/s
60 : 40 % (w/w)	169 s	1.18 mm/s
65 : 35 % (w/w)	190 s	1.05 mm/s
70 : 30 % (w/w)	273 s	0.73 mm/s

The reference mixture (60 : 40 % (w/w); mixture of the reference item barium nitrate with cellulose having the maximum burning rate) had a burning rate of 1.18 mm/s.

The burning rates for the mixtures of the test item with cellulose are shown inTable2.

Table2: Burning rates for the mixtures of test item with cellulose

Mixture of test item : cellulose	Burning time	Burning rate
0 : 100 % (w/w)	276 s	0.72 mm/s
5 : 95 % (w/w)	208 s	0.96 mm/s
10 : 90 % (w/w)	268 s	0.75 mm/s
15 : 85 % (w/w)	284 s	0.70 mm/s
20 : 80 % (w/w)	326 s	0.61 mm/s
30 : 70 % (w/w)	158 s for 25 mm (Flame extinguished after a few cm)	0.16 mm/s
40 : 60 % (w/w)	193 s for 40 mm (Flame extinguished after a few cm)	0.21 mm/s
50 : 50 % (w/w)	Flame extinguished after a few sec, no propagation of combustion)	--

The three highest burning rates for mixtures of test item and cellulose were observed for the ratios 5 : 95 % (w/w), 10 : 90 % (w/w) and 15 : 85 % (w/w). The main tests for these ratios were repeated five times.

The burning rates for the mixtures of the test item with cellulose with the three highest burning rates are shown inTable3.

Table3: Burning rates for the mixtures of test item with cellulose

Mixture test item : cellulose	Test 1	Test 2	Test 3	Test 4	Test 5	Test 6	Min. time	Maximum rate
5 : 95 % (w/w)	208 s	232 s	225 s	211 s	231 s	224 s	208 s	0.96 mm/s
10 : 90 % (w/w)	268 s	255 s	266 s	253 s	257 s	266 s	253 s	0.79 mm/s
15 : 85 % (w/w)	284 s	312 s	282 s	291 s	294 s	289 s	282 s	0.71 mm/s

The highest burning rate of a mixture of test item with cellulose was 0.96 mm/s.

The highest burning rate of a mixture of test item with cellulose (0.96 mm/s) is lower compared to the highest burning rate of a mixture of barium nitrate with cellulose (1.18 mm/s). Due to this result, the test item 7-Aminocephalosporanic acid has no oxidizing properties according to Directive EC 440/2008 A.17.

Interpretation of results:

other: no oxidising properties

Remarks:

Migrated information

Conclusions:

The test item 7-Aminocephalosporanic acid has no oxidizing properties according to Directive EC 440/2008 A.17.

Executive summary:

A preliminary and a main test were performed with mixtures of the test substance and the reference substance barium nitrate with cellulose powder according to Directive EC 440/2008 A.17.

The highest burning rate of a mixture of test item with cellulose (0.96 mm/s) is lower compared to the highest burning rate of a mixture of barium nitrate with cellulose (1.18 mm/s). Due to this result, the test item 7-Aminocephalosporanic acid has no oxidizing properties according to Directive EC 440/2008 A.17.

Description of key information

The test item 7-Aminocephalosporanic acid has no oxidizing properties according to Directive EC 440/2008 A.17.

Key value for chemical safety assessment

Oxidising properties:

non oxidising

Justification for classification or non-classification

Conclusive but not sufficient for classification.