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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
July 24, 2012 to October 26, 2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Comparable to guideline study (OECD109) with acceptable restrictions
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
no
Type of method:
flask method
Key result
Water solubility:
610.7 mg/L
Conc. based on:
test mat.
Loading of aqueous phase:
5 g/L
Incubation duration:
24 h
Temp.:
20 °C
pH:
>= 3.7 - <= 3.8
Details on results:
Mean water solubility: 610.7 mg/L at 20 °C. Standard deviation: 19.4 mg/L.

For the main test three flasks were prepared with an amount of test item and water, and one flask only with water. After stirring and centrifugation the aqueous phases were measured by means of HPLC. The solution of each flask has been measured twice. The results of these measurements are shown inTable4. The values represented in the table are rounded values. The calculation was carried out with the original not rounded values.

Table4: Results of the flask method

flask

1a

2a

3a

4a

measured value [mg/L]

6.16 / 6.11

6.30 / 6.28

5.91 / 5.90

0 / 0

aliquot of the flask [mL]

0.5

0.5

0.5

0.5

total volume after the 1stdilution [mL]

25

25

25

25

aliquot of the 1stdilution [mL]

1

1

1

1

total volume after the 2nddilution [mL]

2

2

2

2

water solubility [mg/L]

615.8 / 610.5

629.9 / 627.6

590.6 / 589.6

0 / 0

average water solubility [mg/L]

613.2

628.7

590.1

0

mean value of the water solubility [mg/L]

610.7

standard deviation [mg/L]

19.4

relative standard deviation [%]

3.2

Conclusions:
Mean water solubility is 610.7 mg/L at 20 °C.
Executive summary:

The water solubility at 20 °C of test item was determined by the flask method, according to OECD Test Guideline 105 and EC No. 440/2008 Part A. Method A.6.

The mean water solubility is 610.7 mg/L at 20 °C.

Description of key information

The mean water solubility is 610.7 mg/L at 20 °C.

Key value for chemical safety assessment

Water solubility:
610.7 mg/L
at the temperature of:
20 °C

Additional information