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EC number: 213-584-9 | CAS number: 989-38-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In an acute oral toxicity study an LD50 of 250 mg/kg was determined for the test item in rats.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Specific details on test material used for the study:
- STABILITY
The stability of the test substance at room temperature in the vehicle DMSO and in water each over a period of 4 hours was verified analytically. - Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Route of administration:
- oral: unspecified
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 0.1 - 30% aqueous suspension in CMC
- Doses:
- 200, 250, 400, 800, 1250, 1600 and 3200 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology - Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 250 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All animals had died in the four highest dose groups after 14 days. For details please refer to the section 'Any other information on results incl. tables'.
- Clinical signs:
- other: 3200 - 800 mg/kg: Dyspnoea and crouched position immediately after application. After hours and on the following days some animals showed apathy, atony, red stained feces and urine, accelerated or intermittent respiration, partly chrouched position.The l
- Gross pathology:
- Stomach hyperemia, cardiac dilation, stomach slightly dilated with fluid contents, diarrheic intestinal contents, organs stained.
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- Under the conditions of this test, an acute oral toxicity LD50 of 250 mg/kg was determined for the test item in rats.
- Executive summary:
In an acute oral toxicity study equivalent to OECD guideline 401, male and femal rats were orally administered with a 0.1 - 30% aqueous suspension of the test substance in CMC. Five animals per sex received the test substance at doses of 200, 250, 400, 800, 1250, 1600 and 3200 mg/kg and were observed for 14 days. All animals had died in the four highest dose groups after 14 days.
In the dose groups 800 to 3200 dyspnoea and crouched position was observed immediately after application. After hours and on the following days some animals showed apathy, atony, red stained feces and urine, accelerated or intermittent respiration, partly chrouched position.The last animals died after 10 days.
The animals of the dose groups 400 to 200 mg/kg showed immediately after the start of the experiment accelerated breathing. In the afternoon and in the follow-up time crouched position, accelerated or irregular breathing, some animals showed atony, partly reddish feces and urine and blood-encrusted snouts. The male animals of the dose 400 mg/kg were without findings after 6 days, while the females still showed crouched position until the end of the experiment. The survivors of the dose 250 and 200 mg/kg were between 4 and 12 days without findings.
Based on these results, an LD50 of 250 mg/kg (m/f) was determined for rats.
Reference
Table 1: Results of the acute oral toxicity test in rats with the test substance
Dosis [mg/kg] |
Conc. [%] |
No. of animals |
Dead animals |
||||
1 hour |
24 hours |
48 hours |
7 days |
14 days |
|||
3200 |
30 |
5 m 5 f |
0/5 0/5 |
5/5 4/5 |
5/5 4/5 |
5/5 4/5 |
5/5 5/5 |
1600 |
16 |
5 m 5 f |
0/5 0/5 |
3/5 4/5 |
3/5 4/5 |
5/5 5/5 |
|
1250 |
10 |
5 m 5 f |
0/5 0/5 |
3/5 4/5 |
4/5 4/5 |
5/5 4/5 |
5/5 5/5 |
800 |
8 |
5 m 5 f |
0/5 0/5 |
0/5 1/5 |
0/5 1/5 |
4/5 3/5 |
5/5 5/5 |
400 |
4 |
5 m 5 f |
0/5 0/5 |
2/5 0/5 |
3/5 2/5 |
3/5 3/5 |
3/5 5/5 |
250 |
4 |
5 m 5 f |
0/5 0/5 |
1/5 0/5 |
1/5 0/5 |
2/5 1/5 |
2/5 2/5 |
200 |
2 |
5 m 5 f |
0/5 0/5 |
0/5 0/5 |
0/5 0/5 |
0/5 0/5 |
|
m: males
f: females
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 250 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In an acute oral toxicity study
equivalent to OECD guideline 401, male and femal rats were orally
administered with a 0.1 - 30% aqueous suspension of the test
substance in CMC (BASF 1973). Five animals per sex received the test
substance at doses of 200, 250, 400, 800, 1250, 1600 and 3200 mg/kg
and were observed for 14 days. All animals had died in the four
highest dose groups after 14 days.
In the dose groups 800 to 3200 dyspnoea and crouched position was
observed immediately after application. After hours and on the
following days some animals showed apathy, atony, red stained feces
and urine, accelerated or intermittent respiration, partly crouched
position.The last animals died after 10 days.
The animals of the dose groups 400 to 200 mg/kg showed accelerated
breathing immediately after the start of the experiment. In the
afternoon and in the follow-up time crouched position, accelerated
or irregular breathing. Some animals showed atony, partly reddish
feces and urine and blood-encrusted snouts. The male animals of the
dose 400 mg/kg were without findings after 6 days, while the females
still showed crouched position until the end of the experiment. The
survivors of the dose 250 and 200 mg/kg were without findings
between 4 and 12 days.
Based on these results, an LD50 of 250 mg/kg (m/f) was determined for
rats.
Justification for classification or non-classification
Classification, Labelling, and Packaging
Regulation (EC) No 1272/2008
The available data are reliable and suitable for classification
purposes under Regulation (EC) No 1272/2008. Based on available data on
acute oral toxicity, the test item is classified as Acute Tox. 3, H301
(toxic if swallowed) according to Regulation (EC) No 1272/2008 (CLP), as
amended for the tenth time in Regulation (EU) No 2017/776.
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