Dipropoxymethane

Toxicity to aquatic algae and cyanobacteria

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

toxicity to aquatic algae and cyanobacteria

Type of information:

(Q)SAR

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

QSAR method based on chemical class principle: ECOSAR (v1.11) from EPISUITE (US EPA)

The substance falls within the applicability domain :
- The substance belongs to the class of neutral organics.
- The log Kow is ≤ 5.
- The substance falls within the applicability domain of the KOWWIN (v1.68) QSAR.
- The molecular weight is ≤ 1000 g/mol.

Principles of method if other than guideline:

QSAR method based on chemical class principle: ECOSAR (v1.11) from EPISUITE (US EPA)

Key result

Dose descriptor:

NOEC

Effect conc.:

8.5 mg/L

Remarks on result:

other: QSAR calculation

Details on results:

ECOSAR Version 1.11 Results Page

SMILES : CCCOCOCCC
CHEM :
CAS Num:
ChemID1:
MOL FOR: C7 H16 O2
MOL WT : 132.20
Log Kow: 1.770 (EPISuite Kowwin v1.68 Estimate)
Log Kow: 2.000 (User Entered)
Log Kow: (PhysProp DB exp value - for comparison only)
Melt Pt: -97.00 (deg C, User Entered for Wat Sol estimate)
Melt Pt: -97.30 (deg C, PhysProp DB exp value for Wat Sol est)
Wat Sol: 3014 (mg/L, EPISuite WSKowwin v1.43 Estimate)
Wat Sol: 3650 (mg/L, User Entered)
Wat Sol: (PhysProp DB exp value)


--------------------------------------
Values used to Generate ECOSAR Profile
--------------------------------------
Log Kow: 2.000 (User Entered)
Wat Sol: 3650 (mg/L, User Entered)



--------------------------------------
ECOSAR v1.11 Class-specific Estimations
--------------------------------------
Neutral Organics
Predicted
ECOSAR Class Organism Duration End Pt mg/L (ppm)
=========================== ================== ======== ====== ==========
Neutral Organics : Fish 96-hr LC50 108.604
Neutral Organics : Daphnid 48-hr LC50 61.666
Neutral Organics : Green Algae 96-hr EC50 45.935
Neutral Organics : Fish ChV 10.616
Neutral Organics : Daphnid ChV 6.014
Neutral Organics : Green Algae ChV 12.029
Neutral Organics : Fish (SW) 96-hr LC50 136.724
Neutral Organics : Mysid 96-hr LC50 101.612
Neutral Organics : Fish (SW) ChV 14.840
Neutral Organics : Mysid (SW) ChV 8.783
Neutral Organics : Earthworm 14-day LC50 229.851

Note: * = asterisk designates: Chemical may not be soluble enough to
measure this predicted effect. If the effect level exceeds the
water solubility by 10X, typically no effects at saturation (NES)
are reported.


------------------------------
Class Specific LogKow Cut-Offs
------------------------------
If the log Kow of the chemical is greater than the endpoint specific cut-offs
presented below, then no effects at saturation are expected for those endpoints.

Neutral Organics:
----------------
Maximum LogKow: 5.0 (Fish 96-hr LC50; Daphnid LC50, Mysid LC50)
Maximum LogKow: 6.0 (Earthworm LC50)
Maximum LogKow: 6.4 (Green Algae EC50)
Maximum LogKow: 8.0 (ChV)



------------------------------------------------------------------------------

Validity criteria fulfilled:

yes

Conclusions:

The long-term toxicity to green algae was also estimated using the ECOSAR model v1.11 included in the EpiSuite program of US-EPA. The estimated chronic value (ChV) is 12.029 mg/L, the corresponding NOEC is 8.5 mg/L. 

Executive summary:

The long-term toxicity to green algae was also estimated using the ECOSAR model v1.11 included in the EpiSuite program of US-EPA. The estimated chronic value (ChV) is 12.029 mg/L, the corresponding NOEC is 8.5 mg/L. 

In ECOSAR, the estimated chronic toxicity is expressed as the chronic value (ChV). The ChV, is defined as the geometric mean of the no observed effect concentration (NOEC) and the lowest observed effect concentration (LOEC). To derive a NOEC, the ChV can be divided by √2 (REACH Guidance R10, Table R10-1).

Reference 2

Endpoint:

toxicity to aquatic algae and cyanobacteria

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From 2011-01-28 to 2011-02-10

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP lab following OECD guidelines

Qualifier:

according to guideline

Guideline:

OECD Guideline 201 (Alga, Growth Inhibition Test)

Deviations:

yes

Remarks:

Average exposure concentrations were used for all evaluations and results. LImit of quantification was used for calculation of the concentrations

GLP compliance:

yes (incl. QA statement)

Analytical monitoring:

yes

Vehicle:

yes

Test organisms (species):

Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)

Water media type:

freshwater

Limit test:

yes

Total exposure duration:

72 h

Duration:

72 h

Dose descriptor:

EC50

Effect conc.:

> 15.8 mg/L

Nominal / measured:

meas. (arithm. mean)

Conc. based on:

test mat.

Basis for effect:

cell number

Duration:

72 h

Dose descriptor:

NOEC

Effect conc.:

1.09 mg/L

Nominal / measured:

meas. (arithm. mean)

Conc. based on:

test mat.

Basis for effect:

cell number

Executive summary:

The test substance, PROPYLAL, was tested for growth inhibition on algae Desmodesmus subspicatus .

The test was performed according to method C.3. - Freshwater Algae and Cyanobacteria, Growth Inhibition Test, Commission Regulation (EC) No. 761/2009, Annex N.

The preliminary test was performed in range of test substance nominal concentrations 1 - 100 mg/L. The analytical results from the preliminary test showed, that concentrations of the test substance PROPYLAL were found under a limit of detection at the end of the test.

According to the calculated Henry's law constant (H = 661 Pa.m³/mol) the test substance PROPYLAL is a volatile substance, which relates to results of analytical measurements in preliminary test.

Though the test substance PROPYLAL was toxic for algae because the highest inhibition of growth rate was 19.6 % and the highest inhibition of yield was 63.5 % in the preliminary test.

Based on the toxicity of the test substance for the yield found in the preliminary test, the full test was performed.

The full test was performed in range of test substance nominal concentrations 4 - 100 mg/L. The analytical results showed that concentrations determinated at the beginning of the test decreased for 98.5 - 100% at the end of the test. Therefore the average exposure concentrations were used for all evaluations and results.

Test results:

72 hour – ErC50 > 15.8 mg/L (average exposure concentration)

72 hour – EyC50 = 5.97 mg/L (average exposure concentration)

(95% confidence limit: 5.14 - 6.80 mg/L)

72 hour- NOECr = 1.09 mg/L (average exposure concentration)

72 hour - NOECy < 1.09 mg/L (average exposure concentration)

Key value for chemical safety assessment

EC50 for freshwater algae:

15.8 mg/L

EC10 or NOEC for freshwater algae:

8.5 mg/L