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EC number: 209-167-6
CAS number: 557-28-8
The skin sensitising potential of zinc oxide (purity 99.69%) was
investigated in female Dunkin Hartley guinea pigs in two well-performed
maximisation tests, conducted according to Directive 96/54/EC B.6 and
OECD guideline 406. Based on the results of a preliminary study, in the
main studies experimental animals (10 in each test) were intradermally
injected with a 20% concentration and epidermally exposed to a 50%
concentration (i.e. the highest practically feasible concentration).
Control animals (5 in each test) were similarly treated, but with
vehicle (water) alone. Approximately 24 hours before the epidermal
induction exposure all animals were treated with 10% SDS. Two weeks
after the epidermal application all animals were challenged with a 50%
test substance concentration and the vehicle.In
the first study, in response to the 50% test substance concentration
skin reactions of grade 1 were observed in 4/10 experimental animals 24
hours after the challenge (40% sensitisation rate), while no skin
reactions were evident in the controls. In contrast, in the second study
no skin reactions were evident in the experimental animals (0%
sensitisation rate), while a skin reaction grade 1 was seen in one
control animal. The skin reaction observed in one control animal is most
likely sign of non-specific irritation.
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