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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
11/05/2017 to 14/06/2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
ISO 13320 (Particle size analysis - Laser diffraction methods)
Deviations:
not specified
GLP compliance:
yes
Other quality assurance:
ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
Type of method:
Laser scattering/diffraction
Type of distribution:
volumetric distribution
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 160405
- Expiration date of the lot/batch: data not available
- Purity test date: data not available

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: data not available
- Solubility and stability of the test substance in the solvent/vehicle: insoluble and well dispersed in silicone oil

TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: none
Mass median aerodynamic diameter:
414.329 µm
Geometric standard deviation:
7.983
Percentile:
D10
Mean:
161.713 µm
St. dev.:
4.123
Percentile:
D50
Mean:
404.344 µm
St. dev.:
7.79
Percentile:
D90
Mean:
859.518 µm
St. dev.:
17.348
Conclusions:
MMAD = 414.329 ± 7.983 µm
D10 = 161.713 ± 4.123 µm
D50 = 404.344 ± 7.790 µm
D90 = 859.518 ± 17.348 µm
Executive summary:

The particle size distribution of Timethylamine-N-oxide was determined according to the method ISO 13320:2009 (Laser Diffraction).

The results of this test are:

MMAD = 414.329 ± 7.983 µm

D10 = 161.713 ± 4.123 µm

D50 = 404.344 ± 7.790 µm

D90 = 859.518 ± 17.348 µm

Description of key information

Laser scattering/diffraction, volumetric distribution. According to ISO 13320 (Particle size analysis - Laser diffraction methods) and GLP.

Mass median aerodynamic diameter: 414.329 μm

D10: 161.713 μm

D50: 404.344 µm

D90: 859.518 µm

Additional information

The particle size distribution of Timethylamine-N-oxide was determined according to the method ISO

13320:2009 (Laser Diffraction).