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Description of key information

Absorption: The most likely route of absorption of Cardanol is through the dermal route. Absorption by the oral and inhalation route is highly unlikely considering the use of the chemical as well as the low vapour pressure of the chemical (0.00005 Pa) respectively.
Distribution: Considering the low water solubility of cardanol, any absorbed chemical shall be distributed through the body via the lipids and not through the blood considering the poor water solubility.
Metabolism: Considering the reported partition coefficient value (Log Kow) of > 6.2, it is expected that the bio-availability of cardanol for metabolism shall be reduced. Any chemical which is not metabolized is expected to be excreted out of the living system either through the urine or faeces.
Excretion: There is no reported data available on the excretion of absorbed cardanol but from the information available on the acute oral toxicity studies, where the LD50 value is > 5000 mg/kg bw, it is expected that the orally administered cardanol was excreted out of the living system of rats, by virtue of which they survived the entire duration of test with no abnormalities detected.
Based upon the data available on the important physico-chemical properties and results of the acute oral and dermal exposure; it can be concluded that cardanol shall have low bio-accumulation potential.

Key value for chemical safety assessment

Bioaccumulation potential:
low bioaccumulation potential

Additional information

There is no data available pertaining to the toxico-kinetics of cardanol. Therefore the absorption, distribution, metabolism and excretion (ADME) behavior have been derived based upon the properties of the chemical and results of the acute oral and dermal toxicity testing. It is also important to note that considering the use of cardanol as an industrial chemical, dermal absorption is the only likely route of absorption. However, in the acute toxicity testing by the dermal route, the LD50 was experimentally determined to be > 2000 mg/kg bw indicating no adverse effect by dermal absorption. The bio-concentration factor (BCF) values for the chemical are also < 500, indicating that the potential for bio-accumulation of cardanol is low

Thus, based on all the above considerations, it is concluded that cardanol shall have low bio-accumulation potential.