Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 947-945-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Principles of method if other than guideline:
- data is predicted using the QSAR toolbox version 3.1
- GLP compliance:
- not specified
- Type of study:
- not specified
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Route:
- other: no data
- Concentration / amount:
- no data
- Concentration / amount:
- no data
- No. of animals per dose:
- no data
- Reading:
- 1st reading
- Group:
- test chemical
- Clinical observations:
- sensitizing
- Remarks on result:
- other: Reading: 1st reading. Group: test group. Clinical observations: sensitizing.
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information EC3 = 6.55 % Criteria used for interpretation of results: EU
- Conclusions:
- Based on QSAR prediction the Reaction mass of Cardanol diene and Cardanol monoene and Cardanol triene was found to be sensitizing to guinea pig (EC3 = 6.5%).
- Executive summary:
Based on QSAR prediction the Reaction mass of Cardanol diene and Cardanol monoene and Cardanol triene was found to be sensitizing to guinea pig (EC3 = 6.5%).
Reference
The prediction was based on dataset comprised from the following descriptors: EC3
Estimation method: Takes average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
(((("a" or "b" or "c" or "d" or "e" ) or "f" ) and ("g" and ( not "h") ) ) and ("i" and "j" ) )
Domain logical expression index: "a"
Referential boundary: The target chemical should be classified as Phenols (Chronic toxicity) by US-EPA New Chemical Categories
Domain logical expression index: "b"
Referential boundary: The target chemical should be classified as Alkene AND Allyl AND Aryl AND Benzyl AND Phenol by Organic functional groups
Domain logical expression index: "c"
Referential boundary: The target chemical should be classified as Allyl AND Benzyl AND Overlapping groups AND Phenol by Organic functional groups (nested)
Domain logical expression index: "d"
Referential boundary: The target chemical should be classified as Alcohol, olefinic attach [-OH] AND Aliphatic Carbon [CH] AND Aliphatic Carbon [-CH2-] AND Aliphatic Carbon [-CH3] AND Aromatic Carbon [C] AND Hydroxy, aromatic attach [-OH] AND Olefinic carbon [=CH- or =C<] AND Olefinic carbon [=CH2] AND Oxygen, one aromatic attach [-O-] by Organic functional groups (US EPA)
Domain logical expression index: "e"
Referential boundary: The target chemical should be classified as Aromatic compound AND Hydroxy compound AND Phenol by Organic functional groups, Norbert Haider (checkmol)
Domain logical expression index: "f"
Similarity boundary:Target: c1(O)cc(CCCCCCCC=CCC=CCCC)ccc1_c1(O)cc(CCCCCCCCCCCCCCC)ccc1_c1(O)cc(CCCCCCCC=CCC=CCC=C)ccc1_c1(O)cc(CCCCCCCC=CCCCCCC)ccc1
Threshold=50%,
Dice(Atom centered fragments)
Domain logical expression index: "g"
Referential boundary: The target chemical should be classified as Not categorized AND Phenol, (tetrapropenyl) derivatives Tetrapropenyl phenol by OECD HPV Chemical Categories
Domain logical expression index: "h"
Referential boundary: The target chemical should be classified as Cresols OR m,p - Cresols by OECD HPV Chemical Categories
Domain logical expression index: "i"
Parametric boundary:The target chemical should have a value of log Kow which is >= 4.73
Domain logical expression index: "j"
Parametric boundary:The target chemical should have a value of log Kow which is <= 12.2
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
Based on studies of target & read across substance reviewed for skin sensitisation from reliable sources having Klimisch rating 2 the weight of evidence approach summary results are presented below
Sr.No
Test
No. of subjects
Species
Result
Remark
1.
Guinea pig maximisation test
-
Guinea pig
sensitising
QSAR Prediction
2.
-
-
Human
sensitising
Publication data
3
Open epicutaneous test
4-8
guinea pig
Not sensitizing
Publication data
4
-
-
Human
Sensitizing
Publication data of RA
5
Skin prick test
3
Human
Sensitizing
Publication data of RA
6
Patch-Test
54
Human
Sensitizing
Publication data of RA
7
-
-
Human
Sensitizing
Publication data of RA
Justification for selection of skin sensitisation endpoint:
The result is experimental. In addition, there is sufficient weight of evidence for the target chemical as well as its close read-across Reaction mass of Cardanol diene and Cardanol monoene and Cardanol triene that indicates a positive sensitizing reaction being produced by cardanol
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Reaction mass of Cardanol diene and Cardanol monoene and Cardanol triene is considered to be sensitizing to skin as per the criteria of CLP regulation set by EU.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.