Registration Dossier
Registration Dossier
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EC number: 213-995-3 | CAS number: 1071-76-7
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- publication
- Title:
- Effect of acute combined exposure to N-butyl alcohol and m-xylene
- Author:
- Korsak S., Swiecz, R., and Jedrychowski R.
- Year:
- 1 993
- Bibliographic source:
- Polish Jor. of Occup. Med. and Environmental Health. 6(1): 35-41
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: other
- Principles of method if other than guideline:
- disturbance of rotarod performance
- GLP compliance:
- not specified
- Test type:
- other: reduction in respiratory rate
Test material
- Reference substance name:
- Butan-1-ol
- EC Number:
- 200-751-6
- EC Name:
- Butan-1-ol
- Cas Number:
- 71-36-3
- Molecular formula:
- C4H10O
- IUPAC Name:
- butan-1-ol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: vapour
- Vehicle:
- air
- Duration of exposure:
- ca. 4 h
- No. of animals per sex per dose:
- 10 male rats per group
- Control animals:
- yes
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- ca. 6 531 ppm
- Based on:
- other: rotarod performance
- Exp. duration:
- 4 h
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- pratically non toxic.
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