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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference
Reference Type:
publication
Title:
Effect of acute combined exposure to N-butyl alcohol and m-xylene
Author:
Korsak S., Swiecz, R., and Jedrychowski R.
Year:
1993
Bibliographic source:
Polish Jor. of Occup. Med. and Environmental Health. 6(1): 35-41

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: other
Principles of method if other than guideline:
disturbance of rotarod performance
GLP compliance:
not specified
Test type:
other: reduction in respiratory rate

Test material

Constituent 1
Reference substance name:
Butan-1-ol
EC Number:
200-751-6
EC Name:
Butan-1-ol
Cas Number:
71-36-3
Molecular formula:
C4H10O
IUPAC Name:
butan-1-ol

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
inhalation: vapour
Vehicle:
air
Duration of exposure:
ca. 4 h
No. of animals per sex per dose:
10 male rats per group
Control animals:
yes

Results and discussion

Effect levels
Key result
Sex:
male
Dose descriptor:
LC50
Effect level:
ca. 6 531 ppm
Based on:
other: rotarod performance
Exp. duration:
4 h

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
pratically non toxic.