Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 213-995-3 | CAS number: 1071-76-7
No studies were conducted on the target substance, zirconium tetrabutanolate. As the target substance hydrolyses rapidly (half-life < 5 minutes) the intrinsic properties are related to hydrolysis products of the target substance. The hydrolysis products include 1-butanol and non-hazardous zirconium dioxide. This information is used as a supporting evidence on the toxicity of the target substance in CSA.
1-butanol is readily absorbed through the skin, intestinal tract, and lungs (Sander, 1933; Theorell and Bonnichsen, 1951; Winer, 1958; Merritt and Tomkins, 1959; Wartburg et al., 1964) and is eliminated after metabolism primarily by alcohol and aldehyde dehydrogenases. Two hours after rats (strain not specified) were given an oral dose of 2,000 mg/kg body weight, the maximum blood-alcohol concentration was 500 mg/l (Gaillard and Derache, 1965). After four hours, the concentration dropped to 150 mg/l, and only 0.03% of the administered dose was excreted in the urine after eight hours.
In another study, CD rats excreted 83.3% of the dose (450 mg/kg body mass) as carbon dioxide and 4.4% in the urine after 24 hours (DiVincenzo and Hamilton, 1979). Beagle dogs dermally exposed through an absorption cell on the thorax absorbed the compound at a rate of 8.8 mg/min per cm 2 over a 60-minute period (DiVincenzo and Hamilton, 1979). In an inhalation study, beagle dogs exposed to 50 ppm BA over a 6-hour period absorbed approximately 55% of the inhaled vapor (DiVincenzo and Hamilton, 1979). (Adapted from UNEP 2004).
Overall, 1-butanol is rapidly absorbed, metabolized, and excreted in rats. Accumulation of n-butanol or its metabolites is unlikely to occur.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again