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EC number: 211-941-3 | CAS number: 717-74-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 16 - June 15, 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- The in vivo test was carried out for the purpose of another regulation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 1,3,5-triisopropylbenzene
- EC Number:
- 211-941-3
- EC Name:
- 1,3,5-triisopropylbenzene
- Cas Number:
- 717-74-8
- Molecular formula:
- C15H24
- IUPAC Name:
- 1,3,5-tris(propan-2-yl)benzene
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Batch No. 6F11027000
- Expiration date of the lot/batch: 17. Nov. 2016
- Purity: 96%
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: S & K-LAP Kft.(Hungary)
- Age at study initiation: Adult, 14 weeks old
- Weight at study initiation: 3038 - 3400 g
- Housing: Animals were housed individually in metal cages
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 20 days in first animal, 21 days in second and third animal
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ± 3 °C
- Humidity (%): 30-70 %
- Air changes (per hr): 10-15 air exchanges/hour by central air-condition system
- Photoperiod (hrs dark / hrs light): 12 hours daily, from 6.00 a.m. to 6.00 p.m.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.1 mL of the unchanged test item
The untreated right eye served as the control
- Duration of treatment / exposure:
- The eyes of the test animals were not washed out.
- Observation period (in vivo):
- 1, 24, 48 and 72 hours after the application.
- Number of animals or in vitro replicates:
- 3 males
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: The eyes of the test animals were not washed out.
SCORING SYSTEM: Draize (1979) and OECD 405 (2012)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Remarks on result:
- probability of weak irritation
- Remarks:
- 1 hour after the single application of test item into the eye of the rabbits, slight redness and chemosis occurred
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Remarks on result:
- probability of weak irritation
- Remarks:
- 1 hour after the single application of test item into the eye of the rabbits, slight redness and chemosis occurred
- Irritant / corrosive response data:
- 1 hour after the single application of test item into the eye of the rabbits, slight redness and chemosis occurred.
24 hours after treatment all animals was free of symptoms. - Other effects:
- - One hour after treatment some hyperemic blood vessels (score 1) were observed in all animals. The swelling of the conjunctivae was different from normal (score 1) in animal No.: 1828.
- 24, 48, and 72 hrs after treatment, all animals were free of symptoms.
- No systemic toxicity was observed on the day of treatment or during the observation period.
- Signs of pain and distress were not observed in animals during the study.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- according to EC 1272/2008 as amended
- Conclusions:
- In conclusion, test item 1,3,5-Triisopropylbenzene applied to the rabbits' eye mucosa caused slight conjunctival irritant effects which were fully reversible within 24 hours.
- Executive summary:
The acute eye irritation study with test item 1,3,5-Triisopropylbenzene was performed in New Zealand White rabbits. The irritation effect of the test item was scoring according to the Draize method (Draize, 1959; OECD Guideline 405, 2012).
The test item was placed into the conjunctival sac of left eye of each animal. The untreated right eye served as control. 0.1 ml of the test item was used for the study, in a single dose. The eyes of the test animals were not washed out.
1 hour after the single application of test item into the eye of the rabbits, slight redness and chemosis occurred. 24 hours after treatment all animals was free of symptoms. The 24/48/72 hour mean cornea opacity score, iris score, and chemosis score was 0.00, 0.00, and 0.00, respectively.
During the study the control eyes of animals were symptom-free. No systemic toxicity was observed. The body weight of animals corresponded to their species and age. Sign of pain and distress as discharge was not observed in animals during the study.
The test item 1,3,5-Triisopropylbenzene applied to the rabbits' eye mucosa caused slight conjunctival irritant effects which were fully reversible within 24 hours.
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