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EC number: 241-481-9 | CAS number: 17464-91-4
Three preliminary tests were carried out with specified amounts of the test item and specified amounts of demineralized water. After each addition of an amount of water, the mixture was stirred for at least 24 hours, and visually checked for any undissolved particles.
Table4: Results of the preliminary test
of test item / mg
Total volume of demineralized water / mL
Appearance of mixture
The preliminary test showed that the water solubility of the test item is < 10 mg/L. According to the preliminary test the water solubility was determined by the column elution method in the main test.
101.0 mg of the test item were dissolved in 100 mL tetrahydrofuran. For charging the columns in each case 25 mL of the test item solution was added to about 3 g of sea sand and the mixtures were shaken. The solvent was then removed under reduced pressure using a rotary evaporator (40 °C, approx. 20 mbar). The dry residues were placed into the columns of the test apparatus, which have afterwards been filled with water (test temperature: 20 °C; water pH at 23 °C: 6.9). After a swelling time of 2 h pumps were started to rinse the test item coated sand with demineralized water. At the end of the study it was confirmed that residual test item remained on the columns. The residual test item was eluted with 50 mL tetrahydrofuran. As blank value the used demineralized water was tested. No signal was detected in the range of the retention time of the test item. The concentration of the test item was quantified by HPLC. Refer to and Table 5 to Table 7 for results.
Rotation period of the fraction collector: 90 min per fraction
Duration of sampling: about 73 h (49 fractions)
Table5: Column elution method, column 1 (approximately 12.5 mL/h)
V / mL
water solubility / mg/L
The water solubility was found to be 1.72 mg/L.
Rotation period of the fraction collector: 45 min per fraction
Duration of sampling: about 73h (98 fractions)
Table6: Column elution method, column 2 (approximately 25.0 mL/h)
The water solubility was found to 1.84 mg/L.
In both columns the concentration of five consecutive fractions was constant within ± 30 %. No increasing or decreasing tendency was observed.
Table7: Coating check
Amount of test item used for coating
Measured concentration of test item in eluate
Amount of test item eluted
Column 12.5 mL/h
2.62 / 2.62
Column 25.0 mL/h
2.02 / 2.02
The coating check was successful. Enough test item remained on the columns.
The water solubility cS of the test item Disperse Brown 4 was 1.78 mg/L (mean value of the columns).
The water solubility cS of the test item Disperse Brown 4 at a temperature of 20 °C was determined according to the column elution method. It was found to:
cS = 1.78 mg/L
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