Registration Dossier
Registration Dossier
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EC number: 274-352-0 | CAS number: 70161-16-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- data is from safety assessment reports
Data source
Reference
- Reference Type:
- secondary source
- Title:
- IUCLID DATASET for the test chemical
- Author:
- OECD SIDS -SIAM
- Year:
- 1 999
- Bibliographic source:
- OECD SIDS, SIAM 9, 29/06/1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- To assess the eye irritation potential of the test chemical in rabbits
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Barium bis[2-chloro-5-[(2-hydroxy-1-naphthyl)azo]toluene-4-sulphonate]
- EC Number:
- 225-935-3
- EC Name:
- Barium bis[2-chloro-5-[(2-hydroxy-1-naphthyl)azo]toluene-4-sulphonate]
- Cas Number:
- 5160-02-1
- Molecular formula:
- C17H13ClN2O4S.1/2Ba
- IUPAC Name:
- Barium bis[2-chloro-5-[(2-hydroxy-1-naphthyl)azo]toluene-4-sulphonate]
- Test material form:
- solid
- Details on test material:
- Name of the test chemical: Barium bis[2-chloro-5-[(2-hydroxy-1-naphthyl)azo]toluene-4-sulphonate]Common name: D&C Red 9Molecular Weight: 888.952 g/molMolecular Formula: C17H13ClN2O4S.1/2BaPhysical State:SolidSubstance Type: Organic
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- no data available
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- no data available
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 24 hours
- Duration of post- treatment incubation (in vitro):
- no data available
- Number of animals or in vitro replicates:
- no data available
- Details on study design:
- no data available
Results and discussion
In vitro
- Other effects / acceptance of results:
- no data available
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No signs of irritation observed
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- No signs of irritation were observed after 24 hours exposure to the test chemical in rabbits.Hence, the test chemical can be considered to be not irritating to rabbit eyes.
- Executive summary:
The ocular irritation potential of the test chemical was assessed in rabbits. The study was performed as per OECD 405 Guidelines. The test chemical was instilled in the eyes of rabbits and exposed till 24 hours. No signs of irritation were observed after 24 hours exposure to the test chemical in rabbits.
Hence, the test chemical can be considered to be not irritating to rabbit eyes.
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