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EC number: 203-694-5
CAS number: 109-67-1
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In a reverse gene mutation assay performed according to the NTP Standard
Protocol (Ames Test), Salmonella typhimurium strains TA 1535, TA 97 and
TA 98 and TA 100 were exposed to 1-pentene diluted in DMSO both in the
presence and absence of metabolic activation system (S9 fraction) from
100 to 10000 µg/plate using the preincubation method. Vehicle (dimethyl
sulphoxide) and positive control groups were also included in
No test material precipitate was observed on the plates at any of the
doses tested in either the presence or absence of S9-mix.
All of the positive control chemicals used in the test induced marked
increases in the frequency of revertant colonies, both with or without
metabolic activation. Thus, the sensitivity of the assay and the
efficacy of the S9-mix were validated.
No significant increases in the frequency of revertant colonies were
recorded for any of the bacterial strains, with any dose of the test
material, either with or without metabolic activation.
Under the test condition, test material is not mutagenic with and
without metabolic activation in S. typhimurium (strains TA1535, TA97,
TA98 and TA100) according to the criteria of the Annex I of the of the
Regulation (EC) No. 1272/2008 (CLP) and to the GHS.
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