Registration Dossier
Registration Dossier
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EC number: 203-694-5 | CAS number: 109-67-1
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- not specified
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Recognised data source, considered as reliable, but raw data with no details.
- Principles of method if other than guideline:
- not specified
- Type of method:
- other: not specified
- Partition coefficient type:
- octanol-water
- Type:
- log Pow
- Partition coefficient:
- 2.2
- Temp.:
- 25 °C
- pH:
- >= 0 - <= 14
- Conclusions:
- The substance has low potential to bioaccumulate in the environment, according to CLP classification criteria for aquatic chronic toxicity (log Kow <4).
- Executive summary:
The CRC Handbook provides a partition coefficient (log Kow) of 2.2 for the substance.
- Endpoint:
- partition coefficient
- Type of information:
- not specified
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Recognised data source, considered as reliable, but raw data with no details.
- Principles of method if other than guideline:
- not specified
- Type of method:
- calculation method (fragments)
- Partition coefficient type:
- octanol-water
- Type:
- log Pow
- Partition coefficient:
- 2.66
- Temp.:
- 25 °C
- pH:
- >= 0 - <= 14
- Conclusions:
- The substance has low potential to bioaccumulate in the environment, according to CLP classification criteria for aquatic chronic toxicity (log Kow <4).
- Executive summary:
The HSDB database provides, as secondary source, physico-chemical data on the substance.
The partition coefficient (log Kow), estimated from Meylan and Howard, is 2.66.
Referenceopen allclose all
estimated log Kow of 2.66
Meylan WM, Howard PH; J Pharm Sci 84: 83-92 (1995)
Description of key information
(average of handbook and calculated value)
Low potential to bioaccumulate in the environment, according to CLP classification criteria for aquatic chronic toxicity (log Kow <4).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.4
Additional information
Three literature sources provide consistent values, between 2.2 and 2.8. The average result of the two references considered as reliable (CRC and HSDB give respectively 2.2 and 2.66) is retained as key data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
