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EC number: 246-791-8 | CAS number: 25291-17-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20 - 24 August 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- 1992
- Qualifier:
- according to guideline
- Guideline:
- other: Fish, acute toxicity test stipulated in the "Testing methods for new chemical substances" (No. 1121002, Pharmaceutical and food safety bureau, Environmental policy bureau, Ministry of the environment, Japan)
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: control, 100 mg/L
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: The test item was added into the dilution water in an Erlenmeyer flask to produce the 100 mg/L test solution. The flask was immediately sealed with a plug not to produce headspace. The solution was stirred by magnetic stirrer for approx. 48 h. After settling for approx. 1 h at 24 ± 1 °C the middle layer of the settled solution was used for testing. The test vessels were covered immediately with a glass lid not to produce headspace.
- Eluate: no
- Differential loading: yes
- Controls: yes, test medium control
- Evidence of undissolved material (e.g. precipitate, surface film, etc.): No, test solutions were clear and colorless at test start and before renewal. - Test organisms (species):
- Oryzias latipes
- Details on test organisms:
- TEST ORGANISM
- Common name: Medaka
- Source: Kurume Laboratory, Chemicals Evaluation and Research Institute, Fukuoka, Japan
- Length at study initiation (length definition, mean, range and SD): 2.3 ± 1.2 cm
ACCLIMATION
- Acclimation period: 27 d
- Acclimation conditions (same as test or not): same as test
- Type and amount of food during acclimation: feed mixture for carp (2C)
- Feeding frequency during acclimation: fed regularly but not fed 24 h before start of exposure
- Health during acclimation (any mortality observed): 0% mortality at 7 d before start of exposure - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Test temperature:
- 24.0 - 24.7 °C
- pH:
- 7.5 - 7.8
- Dissolved oxygen:
- 7.4 - 8.2 mg/L
- Nominal and measured concentrations:
- nominal: control, 100 mg/L
measured: < LOD, 0.117 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: 3 L glass tanks (diameter: 16 cm, depth: 17 cm)
- Type (delete if not applicable): closed with glass lid to avoid headspace
- Aeration: no
- Renewal rate of test solution (frequency/flow rate): every 24 h
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: dechlorinated tap water according to guideline
- Culture medium different from test medium: no
- Intervals of water quality measurement: dissolved oxygen, pH and temperature were measured at test start, before and after renewal and at the end of exposure
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 h light / 8 h dark
- Light intensity: artificieal light of white fluorescent lamps
EFFECT PARAMETERS MEASURED
- Mortality and visible abnormalities were recorded after 3, 24, 48, 72 and 96 h
TEST CONCENTRATIONS
- Range finding study
- Test concentrations: control, 100 mg/L
- Results used to determine the conditions for the definitive study: No mortality was recorded. - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 0.117 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- - Behavioural abnormalities: No abnormal responses were observed during exposure.
- Observations on body length and weight: length: 2.4 ± 0.11 cm; body length: 0.11 ± 0.013 g
- Mortality of control: 0% - Sublethal observations / clinical signs:
Table 1: Measured concentrations of test item in test solutions
Nominal concentration [mg/L]
Measured concentration [mg/L]
At test start
24 h
48 h
72 h
At test end
Geometric mean
Old
New
Old
New
Old
New
Control
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
100
0.329
0.168
0.213
0.0880
0.0831
0.0666
0.0805
0.0768
0.117
- Validity criteria fulfilled:
- yes
- Remarks:
- 0% mortality was recorded in the control.
- Conclusions:
- LC50 (96 h) > 0.117 mg/L (meas. geom. mean)
Reference
Description of key information
LC50 (96 h) > 100 mg/L (nominal); > 0.117 mg/L (meas. (geom. mean))
Key value for chemical safety assessment
Additional information
One experimental study is available investigating the short-term effects of 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene (CAS 25291-17-2) to freshwater fish (Daikin Industries, 2007). The study was performed according to OECD 203 (GLP) using Oryzias latipes as test organism. Due to the high vapour pressure of the substance (4640 Pa at 25 °C) it was ensured during preparation of test solutions that the substance does not evaporate from the test medium by avoiding any headspace in the Erlenmeyer flasks and the test vessels. The test solution (limit concentration of 100 mg/L) was prepared by adding an appropriate amount of test substance to dilution water followed by 48 h of stirring and a settling period of 1 h. The middle layer was used for testing. Test solutions were renewed every 24 h. To verify the exposure concentrations analytical measurements using GC/MS were applied. After 96 h no mortality was observed resulting in a LC50 of > 100 mg/L (nominal) and > 0.117 mg/L (meas. (geom. mean)).
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