Registration Dossier
Registration Dossier
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EC number: 231-832-4 | CAS number: 7758-09-0
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from authoritative database
Data source
Reference
- Reference Type:
- other: Authoritative database
- Title:
- GESTIS-database on hazardous substances
- Author:
- IFA GESTIS
- Year:
- 2 020
- Bibliographic source:
- GESTIS, 2020
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Principles of method if other than guideline:
- Buehler test was performed to evaluate the dermal sensitization potential of the test chemical
- GLP compliance:
- not specified
- Type of study:
- Buehler test
- Justification for non-LLNA method:
- no data available
Test material
- Reference substance name:
- Lithium nitrate
- EC Number:
- 232-218-9
- EC Name:
- Lithium nitrate
- Cas Number:
- 7790-69-4
- Molecular formula:
- HNO3.Li
- IUPAC Name:
- Lithium nitrate
- Test material form:
- solid
- Details on test material:
- Name of the test chemical: Lithium nitrate
Molecular Formula: LiNO3
Molecular Weight: 68.94 g/mol
Substance Type: Inorganic
Physical State: Solid
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- no data available
Study design: in vivo (non-LLNA)
Induction
- Route:
- other: no data available
- Vehicle:
- not specified
- Concentration / amount:
- no data available
- Day(s)/duration:
- no data available
- Adequacy of induction:
- not specified
Challenge
- No.:
- #1
- Route:
- other: not specified
- Vehicle:
- not specified
- Concentration / amount:
- no data available
- Day(s)/duration:
- no data available
- Adequacy of challenge:
- not specified
- No. of animals per dose:
- no data available
- Details on study design:
- no data available
- Challenge controls:
- no data available
- Positive control substance(s):
- not specified
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Group:
- test chemical
- Dose level:
- no data available
- No. with + reactions:
- 0
- Clinical observations:
- No dermal reactions were observed at the treatment sites of the test animals after exposure to the test chemical
- Remarks on result:
- no indication of skin sensitisation
Applicant's summary and conclusion
- Interpretation of results:
- other: not sensitizing
- Conclusions:
- No dermal reactions were observed at the treatment sites of the test animals after exposure to the test chemical. Hence, the test chemical can be considered to be not sensitizing to skin.
- Executive summary:
Buehler test was performed to evaluate the dermal sensitization potential of the test chemical. The study was performed according to OECD 406 Guidelines. No dermal reactions were observed at the treatment sites of the test animals after exposure to the test chemical. Hence, the test chemical can be considered to be not sensitizing to skin.
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