Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Acute inhalation toxicity of test chemical
Author:
Lewis, RJ Sr
Year:
2004
Bibliographic source:
SAX's dangerous properties of industrial materials
Reference Type:
review article or handbook
Title:
Acute inhalation toxicity of Potassium nitrite (CAS no: 7758-09-0) in mouse.
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
HSDB (Hazardous Substances Data Bank), US national Library of Medicine, 2017.
Reference Type:
review article or handbook
Title:
Acute inhalation toxicity of Potassium nitrite (CAS no: 7758-09-0) in mouse.
Author:
U.S. National Library of Medicine
Year:
2021
Bibliographic source:
ChemIDplus, A TOXNET DATABASE, Lite Browse Advanced, 2017.
Reference Type:
other: Authoritative database
Title:
Acute inhalation toxicity of Potassium nitrite (CAS no: 7758-09-0) in mouse.
Author:
Jay A. Brown
Year:
2017
Bibliographic source:
Haz-Map®: Information on Hazardous Chemicals and Occupational Diseases, U.S. National Library of Medicine, October 2017.
Reference Type:
review article or handbook
Title:
Acute inhalation toxicity of Potassium nitrite (CAS no: 7758-09-0) in mouse.
Author:
Michael Ash
Year:
2004
Bibliographic source:
Handbook of Preservatives, 2004
Reference Type:
review article or handbook
Title:
Acute inhalation toxicity of Potassium nitrite (CAS no: 7758-09-0) in mouse.
Author:
S D Gangolli
Year:
2007
Bibliographic source:
The Dictionary of Substances and their Effects (DOSE): O-S, Royal Society of Chemistry, 2007.
Reference Type:
other: Authoritative database
Title:
Acute inhalation toxicity of Potassium nitrite (CAS no: 7758-09-0) in mouse
Author:
GSBL
Year:
2017
Bibliographic source:
GSBL, Joint Substance Data Pool of the German Federal Government and the German Federal States, 2017.
Reference Type:
other: Secondary source
Title:
Toxicity Effects - CAS Registry Number: 7758-09-0.
Author:
National Toxicology Program
Year:
2015
Bibliographic source:
National Library of Medicine's Hazardous Substance Database, 2015.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute inhalation toxicity of Potassium nitrite (CAS no: 7758-09-0) in mouse.
GLP compliance:
no
Test type:
other: Acute inhalation toxicity
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Potassium nitrite
EC Number:
231-832-4
EC Name:
Potassium nitrite
Cas Number:
7758-09-0
Molecular formula:
HNO2.K
IUPAC Name:
potassium nitrite
Test material form:
solid
Details on test material:
- IUPAC Name: Potassium nitrite
- InChI: 1S/K.HNO2/c;2-1-3/h;(H,2,3)/q+1;/p-1
- Smiles: N(=O)[O-].[K+]
- Molecular formulae:KNO2
- Molecular weight :85.103 g/mol
- Substance type:Inorganic
- Physical state:Solid

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: dust
Duration of exposure:
2 h
Concentrations:
85000 mg/m3
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
- Other examinations performed: Animals were observed for mortality and clinical signs.

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LC50
Effect level:
85 000 mg/m³ air (nominal)
Based on:
test mat.
Exp. duration:
2 h
Remarks on result:
other: No data
Mortality:
50% mortality observed
Clinical signs:
other:
Body weight:
No data
Gross pathology:
No data
Other findings:
No data

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
The acute inhalation toxicity dose LC50 value was considered to be 85000 mg/m3, when mice were exposed with Potassium nitrite (CAS no: 7758-09-0) by inhalation route for 2 hours.
Executive summary:

Acute inhalation toxicity study of Potassium nitrite (CAS no: 7758-09-0)was conducted in mice at the dose concentration of 85000 mg/m3.Animals were observed for mortality and clinical signs.50% mortality was observed. Behavioral changes were observed such as, sleep, excitement, muscle contraction or spasticity. Therefore, LC50valuewasconsidered to be 85000 mg/m3, whenmice were exposed withPotassium nitrite (CAS no: 7758-09-0) by inhalation route for 2 hours.