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Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from publication

Data source

Reference
Reference Type:
review article or handbook
Title:
Final Report on the Safety Assessment of test chemical
Author:
Cosmetic Ingredient Review
Year:
1981
Bibliographic source:
JOURNAL OF THE AMERICAN COLLEGE OF TOXICOLOGY ;Volume 7, Number 6,1981

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
A modified Draize ocular irritation test was conducted to evaluate the irritancy of test chemical to the rabbit eye.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Potassium Sorbate
Cas Number:
590-00-1
Molecular formula:
C6H7KO2
IUPAC Name:
Potassium Sorbate
Test material form:
solid
Details on test material:
Name of test material (as cited in study report): Potassium Sorbate
- Molecular formula: C6H7KO2
- Molecular: 150.217 g/mol
- Substance type: Organic
- Smiles: C(=C\C=C\C)\C(=O)[O-].[K+]
- InChI: 1S/C6H8O2.K/c1-2-3-4-5-6(7)8;/h2-5H,1H3,(H,7,8);/q;+1/p-1/b3-2+,5-4+;

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
No data

Test system

Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
1, 5, and 10%
Duration of treatment / exposure:
24 hours
Observation period (in vivo):
Eyes were scored at 1, 2, and 24 h and daily thereafter until all irritation had disappeared.
Number of animals or in vitro replicates:
3 rabbits
Details on study design:
No data

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
24 h
Score:
0
Max. score:
110
Remarks on result:
other: No ocular irritation was observed in treated rabbits.
Irritant / corrosive response data:
No data
Other effects:
No data

Applicant's summary and conclusion

Interpretation of results:
other: Not irritating
Conclusions:
The test material was considered to be not irritating to the eyes of treated rabbits.
Executive summary:

A modified Draize ocular irritation test was conducted to evaluate the irritancy of test chemical to the three rabbit eye.The chemical was instilled into the eyes of each rabbit at a dose of 1, 5, and 10% and eyes were scored at 1, 2, and 24 h and daily thereafter until all irritation had disappeared.The test chemical had an ocular irritation index of 0 at all concentrations (at 24 h) Therefore, the test chemical was considered to be not irritating to the rabbits’ eyes.