Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

acute toxicity: inhalation
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because exposure of humans via inhalation is not likely taking into account the vapour pressure of the substance and/or the possibility of exposure to aerosols, particles or droplets of an inhalable size
Justification for type of information:
TSH has a low vapour pressure and the use as a blowing agent does not lead to the formation of aerosols or particles.

Due to the possible breakdown product from hydrolysis, a precautionary approach is used.

No reliable experimental data is available for toluene-4-sulphonohydrazide (TSH). However, data on the presumed breakdown product of Toluene-4-sulphonohydrazid, hydrazine (CAS No. 302-01-2) shows an LC50 of 570 ppm (0.759 mg/L); and has a harmonized classification for Acute Tox. 3, H331 (toxic if inhaled). Based on the acute toxicity of the presumed breakdown product, hydrazine, it is considered appropriate to classify toluene-4-sulphonohydrazide (TSH) as Acute Tox. 3, H331 without further testing.

Data source

Materials and methods

Results and discussion

Applicant's summary and conclusion