Ethyl propionate

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2015-02-18 to 2015-02-18

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)

Deviations:

yes

Remarks:

Due to technical reasons, standards were injected separately instead of simultaneously.

Qualifier:

according to guideline

Guideline:

EU Method A.8 (Partition Coefficient)

Deviations:

yes

Remarks:

Due to technical reasons, standards were injected separately instead of simultaneously.

GLP compliance:

yes (incl. QA statement)

Remarks:

issued 2013-11-05

Type of method:

HPLC method

Partition coefficient type:

octanol-water

Analytical method:

high-performance liquid chromatography

Key result

Type:

log Pow

Partition coefficient:

1.31

Temp.:

22.1 °C

pH:

7

Table 1: Retention times, Capacity Factors and Partition Coefficients of test item

Test Item	tR[min]	k	log k	log Pow
				1^stCalibration	2^ndCalibration
	2.362	3.80	0.580	1.31 ± 0.05 1.17 to 1.44 (95 % Cl)	1.31 ± 0.05 1.17 to 1.44 (95 % Cl)
	2.362	3.80	0.580
Mean	2.362	3.80	0.580	1.31

tR       : Retention time

k         : Capacity factor test item

Pow    : Partition Coefficient (n-octanol / water)

CI       : Confidence Interval

 

The mean temperature of 22.1 °C was inside the ranges of 20 -25°C±1°C during the course of the study.

The HPLC void time (to) was determined by threefold injection of a solution of 5 mg/L NaNO3.

Serial no.	To [min]
1	0.492
2	0.492
3	0.492
MEAN	0.492

Regression Line: The correlation coefficient r for both calibartions was >0.9

	1st calibration	2^ndcalibration
Slope	2.522	2.522
Y-intercept	-0.1545	-0.1545
r²	0.9863	0.9863

 

Table 2: Calibration Data of the Reference Items

Reference item	log Pow	1^stCalibration			2^ndCalibration
		tR1[min]	k	log k	tR2[min]	k	log k
2-Butanone	0.3	1.325	1.69	0.228	1.324	1.69	0.228
Aniline	0.9	1.723	2.50	0.398	1.723	2.50	0.398
Acetanilide^1)	1.0	1.379	1.80	0.255	1.378	1.80	0.255
Benzonitrile	1.6	2.798	4.69	0.671	2.798	4.69	0.671
Nitrobenzene	1.9	3.686	6.49	0.812	3.685	6.49	0.812
Methyl benzoate	2.1	3.936	7.00	0.845	3.936	7.00	0.845
Toluene	2.7	7.900	15.1	1.18	7.900	15.1	1.18

t_R1                                : Retention time 1. Injection

t_R2                                : Retention time 2. Injection

k                                   : Capacity factor reference item

log Pow                         : Decadic logarithm of the Partition Coefficient (n-octanol / water)

¹⁾                                  : Results of this reference item were determined to be an outlier (outside the 95 % confidence interval) and not taken into account.

Conclusions:

A log Pow of 1.31 was determined for the test item.

Executive summary:

The test item has a partition coefficient of 1.31 at 22.1°C as determined by HPLC method according to EU Method A.8, and OECD Test Guideline 117 (2004).

Description of key information

log Pow = 1.31

Key value for chemical safety assessment

Log Kow (Log Pow):

1.31

at the temperature of:

22.1 °C

Additional information

The test item has a partition coefficient of 1.31 at 22.1 °C as determined by HPLC under GLP in accordance with EC No. 440/2008 Method A.8 and OECD Test Guideline 117 (2004).