Registration Dossier
Registration Dossier
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EC number: 203-291-4 | CAS number: 105-37-3
Endpoint summary
Administrative data
Description of key information
As a weight of evidence approach, three in vitro assays were carried out, namely DPRA, LuSens and h-CLAT for Ethyl caproate (Ethyl hexanoate) as a Read -across substance.
The DPRA study was negative as the test substance showed no chemical reactivity under the current conditions. The LuSens assay showed a negative result regarding sensitization as the test substance did not have a keratinocyte activation potential. The h-CLAT assay was positive regarding sensitization as the substance activated dendritic cells.
Based on a weight of evidence approach according to Bauch et al 2012 two negative results drive the prediction of a test substance to be a non-sensitizer.
Bauch C. et al, (2012), Regul Toxicol Pharmacol, 63(3), 489 -504
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on the available in vitro result for the read-across substance ethyl caproate, the substance is not classified as sensitising according to Regulation (EC) No 1272/2008.
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