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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
18 January 2017 to 10 February 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient - HPLC Method)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
> 10
Temp.:
40 °C
pH:
6.6
Details on results:
RESULTS
- The estimated Log10 Pow for the representative structure of the test item was calculated to be ≥ 14.
- Typical chromatography for the definitive test is presented in Appendix 1 (attached).
- Retention times of the dead time and retention times, capacity factors (k’) and Log10 Pow values for the reference standards are shown in Table 17 (attached).
- The calibration curve from which the sample results were taken is shown in Figure 5 (attached).
- Retention times, capacity factor and Log10 Pow values determined for the sample are shown in Table 18 (attached).
Conclusions:
The partition coefficient of the test item has been determined to be greater than 1.0 x 10E10 with Log10 Pow > 10.0.
Executive summary:

GUIDELINE

The determination was carried out using the HPLC method and a procedure designed to be compatible with Method A.8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004.

 

RESULTS

The partition coefficient of the test item has been determined to be greater than 1.0 x 10E10 with Log10 Pow > 10.0.

Description of key information

The partition coefficient of the test item has been determined to be greater than 1.0 x 10E10 with Log10 Pow > 10.0 (OECD 117 and EU Method A.8).

Key value for chemical safety assessment

Log Kow (Log Pow):
10
at the temperature of:
40 °C

Additional information

GUIDELINE

The determination was carried out using the HPLC method and a procedure designed to be compatible with Method A.8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004.

 

RESULTS

The partition coefficient of the test item has been determined to be greater than 1.0 x 10E10 with Log10 Pow > 10.0.