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EC number: 701-207-5 | CAS number: 1950616-36-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to the O.E.C.D. test guideline 203 with GLP compliance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 1212
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1-[3-(aminomethyl)phenyl]methanamine; 2,4-bis[({[3-(aminomethyl)phenyl]methyl}amino)methyl]phenol; 2,6-bis[({[3-(aminomethyl)phenyl]methyl}amino)methyl]-4-[(4-hydroxyphenyl)methyl]phenol; 2-[({[3-(aminomethyl)phenyl]methyl}amino)methyl]-4-[(4-hydroxyphenyl)methyl]phenol; 2-[({[3-(aminomethyl)phenyl]methyl}amino)methyl]phenol; phenol
- EC Number:
- 701-207-5
- Cas Number:
- 1950616-36-0
- Molecular formula:
- (C8 H12 N2 . C6 H6 O . C H2 O)x
- IUPAC Name:
- 1-[3-(aminomethyl)phenyl]methanamine; 2,4-bis[({[3-(aminomethyl)phenyl]methyl}amino)methyl]phenol; 2,6-bis[({[3-(aminomethyl)phenyl]methyl}amino)methyl]-4-[(4-hydroxyphenyl)methyl]phenol; 2-[({[3-(aminomethyl)phenyl]methyl}amino)methyl]-4-[(4-hydroxyphenyl)methyl]phenol; 2-[({[3-(aminomethyl)phenyl]methyl}amino)methyl]phenol; phenol
- Test material form:
- other: Liquid at room temperature.
- Details on test material:
- As per IUCLID5 Sections 1.1. 1.2. and 4.1.
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- For test concentrations prepared in the range- finding test, stock solutions of the test substance were prepared at concentrations of 10, 50 and 100 mg/L by adding the required nominal amount of test substance in the diluent, laboratory water and mixing the solution for approximately 1 hour and 20 minutes. For test concentrations prepared in the definitive test, stock solutions were prepared for each concentration individually by adding the required nominal amount of test substance in the diluent, and mixing the solution for approximately 3.5 hours.
Test organisms
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- Rainbow Trout, Oncorhynchus mykiss, were acquired from Trout Lodge Trout Farm (Sumner, Washington). There weight range was 0.157-0.256 gm and length was 21-24mm. All fish were held in the laboratory at least 12 days before being placed on study. The environmental conditions were a 16-hours light/8-hours dark cycle, dissolved oxygen concentration of > 60% saturation and temperature of 14-15°C. In the definitive test, fish were fed daily until 48 hours before the test was started. Fish were not fed during the test.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Post exposure observation period:
- None.
Test conditions
- Hardness:
- Total hardness of 90 mg/L CaCO3
- Test temperature:
- 14-15°C
- pH:
- 8.0
- Dissolved oxygen:
- > 60% saturation
- Salinity:
- No data
- Nominal and measured concentrations:
- 10, 20, 40, 80 and 160 mg/L nominal
- Details on test conditions:
- Treatment was conducted in 2-gallon glass aquaria; filled with 8 L of the appropriate solution of moderately hard laboratory freshwate and test substance. The definitive test was conducted using concentrations of 10, 20, 40, 80 and 160 mg/L of the test substance. Each concentration consisted of three replicates of ten fish. Organisms were randomly placed, individually, into each aquarium containing the appropriate concentration of test substance. Three replicates often organisms were not exposed to test substance and served as controls to demonstrate the condition of the test population. At 6, 24, 48, 72 and 96 hours following dosing, each aquarium was examined for mortality, and the number of live fish was recorded. The following measurements were made at dosing and daily afier dosing: dissolved oxygen, temperature, conductivity and pH of the controls and treated containers.
- Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- ca. 25.9 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95% Confidence Limits = 18.3-32.5 mg/L.
- Details on results:
- Survival at 10 mg/L test substance was 100% at 96 hr. At 20 mg/L test substance survivak was 70% at 96 hr. Dose levels of 40 mg/L and greater resulted in complete mortality. Generally, mortality at the high dose levels was seem to occur within 24 hr of exposure to the test substance.
- Reported statistics and error estimates:
- The NOEC (No Observed Effect Concentration) of 10 mg/L and LC50 (median lethal concentration) were determined by a commercially available statistical program (ToxCalc Version 5.OTM). The Linear Interpolation mode was selected for the determination in this case.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test substance was found to have a 96 hr LC50 value of approximately 25.9 mg/L with 95% confidence limits of 18.3-32.5 mg/L for the rainbow trout.
- Executive summary:
The test substance, Formaldehyde, polymer with 1,3 -benzenedimethanamine and phenol was evaluated for acute aquatic toxicity to the rainbow trout in an O.E.C.D. test guideline no. 203 study. The test substance was found to have a 96 hr LC50 value of approximately 25.9 mg/L with 95% confidence limits of 18.3-32.5 mg/L for the rainbow trout.
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