Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 915-640-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Three in vivo studies on skin irritation on the registered substance are available that are supported by data from two other category members.
Six in vivo eye irritation studies on the registered substance, and one in vitro study on a category member are available. Additional in vivo eye irritation studies are available on other category members.
The ADPODS category members differ in structure and length of their alkyl side chains (refer to full read-across ADPODS category justification document). These structural differences do not affect/change the overall irritation potential for any of the category members including the registered substance, as demonstrated by the consistency in eye and skin testing outcomes and classifications.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was not conducted according to guideline/s and GLP but the report contains sufficient data for interpretation of study results.
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The skin irritation test included topical application of the material to intact and abraded skin on the abdomen of two male New Zealand White
rabbits. Both application sites on one rabbit were moistened with 0.5 ml of water, while the material was applied under dry conditions on the
other rabbit. The rabbits received either three (abraded sites) or five (intact sites) daily 0.5 g applications. The animals were on study for
eight days. - GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Two male rabbits were used for the skin irritation test.
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: intact and abraded
- Vehicle:
- other: unchanged and moistened
- Controls:
- no
- Amount / concentration applied:
- 0.5 g,
Both application sites on one rabbit were moistened with 0.5 ml of water, while the material was applied under dry conditions on the
other rabbit. - Duration of treatment / exposure:
- The rabbits received either three (abraded sites) or five (intact sites) daily 0.5 g applications. The test material was left in place for 24 hours.
- Observation period:
- 8 days
- Number of animals:
- 2
- Details on study design:
- The skin irritation test included topical application of the material to intact and abraded skin on the abdomen of two male New Zealand White
rabbits. Both application sites on one rabbit were moistened with 0.5 ml of water, while the material was applied under dry conditions on the
other rabbit. The rabbits received either three (abraded sites) or five (intact sites) daily 0.5 g applications. The test material was applied under a cotton pad and held in place with a cloth bandage. The test material was left in place for 24 hours. The animals were on study for eight days. - Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 24, 48, 72, 96 hours and 8 days
- Score:
- 1
- Max. score:
- 6
- Reversibility:
- other: not applicable
- Remarks on result:
- other: Intact abdomen- dry patch
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 24, 48, 72 and 96 h and 8 days
- Score:
- 1
- Max. score:
- 6
- Reversibility:
- other: not applicable
- Remarks on result:
- other: Intact abdomen- dry patch
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 24 h
- Score:
- 3
- Max. score:
- 6
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: Abraded abdomen- dry patch; Cotton glued on skin, erythema may be due to mechanical injury.
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 48 and 72 h
- Score:
- 4
- Max. score:
- 6
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: Abraded abdomen- dry patch
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 96 h
- Score:
- 3
- Max. score:
- 6
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: Abraded abdomen- dry patch
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 8 days
- Score:
- 1
- Max. score:
- 6
- Reversibility:
- other: not applicable
- Remarks on result:
- other: Abraded abdomen- dry patch
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 24, 48, 72 and 96 h and 8 days
- Score:
- 1
- Max. score:
- 6
- Reversibility:
- other: not applicable
- Remarks on result:
- other: Abraded abdomen- dry patch
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 24 h
- Score:
- 3
- Max. score:
- 6
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: Intact abdomen- wet patch; Cotton glued on skin, erythema may be due to mechanical injury.
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 48 h
- Score:
- 4
- Max. score:
- 6
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: Intact abdomen- wet patch; Cotton glued on skin, erythema may be due to mechanical injury.
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 72 and 96 h
- Score:
- 3
- Max. score:
- 6
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: Intact abdomen- wet patch; Cotton glued on skin, erythema may be due to mechanical injury.
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 8 days
- Score:
- 1
- Max. score:
- 6
- Reversibility:
- other: not applicable
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 24, 48, 72, and 96 h and 8 days
- Score:
- 1
- Max. score:
- 6
- Reversibility:
- other: not applicable
- Remarks on result:
- other: Intact abdomen- wet patch
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 24 h
- Score:
- 3
- Max. score:
- 6
- Reversibility:
- fully reversible within: 96 h
- Remarks on result:
- other: Abraded abdomen- wet patch; Cotton glued on skin, erythema may be due to mechanical injury.
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 48 h
- Score:
- 4
- Max. score:
- 6
- Reversibility:
- fully reversible within: 96 h
- Remarks on result:
- other: Abraded abdomen- wet patch; Cotton glued on skin, erythema may be due to mechanical injury.
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 72 h
- Score:
- 3
- Max. score:
- 6
- Reversibility:
- fully reversible within: 96 h
- Remarks on result:
- other: Abraded abdomen- wet patch; Cotton glued on skin, erythema may be due to mechanical injury.
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 96 h and 8 days
- Score:
- 1
- Max. score:
- 6
- Reversibility:
- other: not applicable
- Remarks on result:
- other: Abraded abdomen- wet patch
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 24, 48, 72 and 96 h and 8 days
- Score:
- 1
- Max. score:
- 6
- Reversibility:
- other: not applicable
- Remarks on result:
- other: Abraded abdomen- wet patch
- Irritant / corrosive response data:
- No irritation was observed when the test material was administered unmoistened (dry patch) to intact skin after prolonged and repeated contact. Slight to moderate erythema was observed after prolonged and repeated contact under moistened conditions (wet patch) and on the abraded site under unmoistened (dry patch)conditions. The dermal response was attributed to mechanical injury. The test material appeared to glue the cotton patch to the skin when moisture was present and removal of the patch was difficult. Results of the skin irritation test indicated the test material is unlikely to be absorbed in acutely toxic amounts.
- Other effects:
- None
- Interpretation of results:
- other: Not categorized, irritation was a result of mechanical injury
- Remarks:
- Criteria used for interpretation of results: other: EU GHS
- Conclusions:
- No irritation was observed when the test material was administered unmoistened (dry patch) to intact skin after prolonged and repeated contact. Slight to moderate erythema was observed after prolonged and repeated contact under moistened conditions (wet patch) and on the abraded site under unmoistened (dry patch)conditions. The dermal response was attributed to mechanical injury. The test material appeared to glue the cotton patch to the skin when moisture was present and removal of the patch was difficult. Results of the skin irritation test indicated the test material is unlikely to be absorbed in acutely toxic amounts.
- Executive summary:
The test material, XU-40340.00 DOWFAX 3B2, powder form, was submitted by the Specialty Chemicals Technical Services & Development Department, The Dow Chemical Company, Midland, MI. The material is of interest for use in the agriculture, cleaning, and textile industries. Standard acute toxicologic tests were conducted and included the acute oral toxicity, skin irritation, and eye irritation studies.
Topical application of the test material to the skin of a New Zealand White rabbit, under dry conditions, resulted in no irritation after prolonged and repeated contact. Slight to moderate- erythema was observed under moistened conditions after prolonged and repeated contact. The dermal response was attributed to mechanical injury. The test material appeared to glue the cotton patch to the skin when moisture was present and removal of the patch was difficult.
Reference
None
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was not conducted according to guideline/s and GLP but the report contains sufficient data for interpretation of study results.
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The eye irritation test included instillation of an aliquot of 0.1 g of the test material into each conjunctival sac of a male New.Zealand White rabbit. The right eye was washed for two minutes with tap water after a 30-second exposure. The left eye was not washed immediately after exposure. At various time intervals both eyes were examined for conjunctival irritation, corneal injury and irritation of the iris.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Male New Zealand White rabbit
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5g
- Duration of treatment / exposure:
- Washed eye- 30 second exposure
Unwashed eye - Observation period (in vivo):
- 21 days
- Number of animals or in vitro replicates:
- 1
- Details on study design:
- The eyes of the rabbit were established as being without defects or irritation 24 hours prior to study initiation. The eye irritation test included instillation of an aliquot of 0.1 g of the test material into each conjunctival sac of a male New Zealand White rabbit. The right eye was washed for two minutes with tap water after a 30-second exposure. The left eye was not washed immediately after exposure. At various time intervals both eyes were examined for conjunctival irritation, corneal injury and irritation of the iris. The eyes were anesthetized if moderate pain eas observed or anticipated. A drop of 5% aqueous fluorescein stain was used to aid in assessing corneal injury.
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 1, 24, 48, and 72 h and 7, 14 and 21 days
- Score:
- 4
- Max. score:
- 6
- Reversibility:
- not reversible
- Remarks on result:
- other: eye- not washed
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: 1, 24, 48 and 72 h and 7 days
- Score:
- 4
- Max. score:
- 6
- Reversibility:
- not fully reversible within: 21 days
- Remarks on result:
- other: eye- not washed and after stain
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: 14 and 21 days
- Score:
- 3
- Max. score:
- 6
- Reversibility:
- not fully reversible within: 21 days
- Remarks on result:
- other: eye- not washed and after stain
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 1 h
- Score:
- 3
- Max. score:
- 6
- Reversibility:
- not fully reversible within: 21 days
- Remarks on result:
- other: eye- not washed
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 24 and 48 h
- Score:
- 4
- Max. score:
- 6
- Reversibility:
- not fully reversible within: 21 days
- Remarks on result:
- other: eye- not washed
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 72 h, 7, 14 and 21 days
- Score:
- 3
- Max. score:
- 6
- Reversibility:
- not fully reversible within: 21 days
- Remarks on result:
- other: eye- not washed
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 1 h
- Score:
- 3
- Max. score:
- 6
- Reversibility:
- not fully reversible within: 21 days
- Remarks on result:
- other: eye- washed
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 24, 48, and 72 h and 7 and 14 days
- Score:
- 4
- Max. score:
- 6
- Reversibility:
- not fully reversible within: 21 days
- Remarks on result:
- other: eye- washed
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 21 days
- Score:
- 3
- Max. score:
- 6
- Reversibility:
- not fully reversible within: 21 days
- Remarks on result:
- other: eye- washed
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: 1, 24, 48, and 72 h and 7 days
- Score:
- 4
- Max. score:
- 6
- Reversibility:
- not fully reversible within: 21 days
- Remarks on result:
- other: eye- washed and after stain
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: 14 days
- Score:
- 3
- Max. score:
- 6
- Reversibility:
- not fully reversible within: 21 days
- Remarks on result:
- other: eye- washed and after stain
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: 21 days
- Score:
- 2
- Max. score:
- 6
- Reversibility:
- not fully reversible within: 21 days
- Remarks on result:
- other: eye- washed and after stain
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 1 h
- Score:
- 2
- Max. score:
- 6
- Reversibility:
- not fully reversible within: 21 days
- Remarks on result:
- other: eye- washed
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 24, 48 and 72 h and 7 days
- Score:
- 3
- Max. score:
- 6
- Reversibility:
- not fully reversible within: 21 days
- Remarks on result:
- other: eye- washed
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 14 and 21 days
- Score:
- 2
- Max. score:
- 6
- Reversibility:
- not fully reversible within: 21 days
- Remarks on result:
- other: eye- washed
- Irritant / corrosive response data:
- The eye irritation test included instillation of an aliquot of 0.1 g of the test material into each conjunctival sac of a male New.Zealand White rabbit. The single exposure resulted in moderate discomfort, moderate conjunctival redness and swelling, moderate reddening of the iris, and moderate corneal injury. Ocular effects were still present in both eyes at day 21 of the test and included slight to moderate conjunctival irritation, slight corneal injury, and slight reddening of the iris. Ophthalmic anesthetic was administered to alleviate discomfort experienced by the rabbit.
- Other effects:
- None
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Remarks:
- Not reversible
- Conclusions:
- A single exposure of New Zealand White rabbit eyes to the test material resulted in moderate discomfort, moderate conjunctival redness and swelling , moderate reddening of the iris, and moderate corneal injury. Ocular effects were still present in both eyes at day 21 of the test and included slight to moderate conjunctival irritation, slight corneal injury, and slight reddening of the iris. Ophthalmic anesthetic was administered to alleviate discomfort experienced by the rabbit.
- Executive summary:
The test material, XU-40340.00 DOWFAX 3B2 powder form, was submitted by the Specialty Chemicals Technical Services & Development Department, The Dow Chemical Company, Midland, MI. The material is of interest for use in the agriculture, cleaning, and textile industries. Standard acute toxicologic tests were conducted and included the acute oral toxicity, skin irritation, and eye irritation studies.
A single exposure of New Zealand White rabbit eyes to the test material resulted in moderate discomfort, moderate conjunctival redness and swelling , moderate reddening of the iris, and moderate corneal injury. Ocular effects were still present in both eyes at day 21 of the test and included slight to moderate conjunctival irritation, slight corneal injury, and slight reddening of the iris. Ophthalmic anesthetic was administered to alleviate discomfort experienced by the rabbit.
Reference
None
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation:
This substance has been tested in three in vivo skin irritation assays. The key study for this endpoint is the assay demonstrated minimal irritation, but not sufficient to warrant classification. Similar (minimal) irritation potential was seen with the other ADPODS category members tested for skin irritation.
Eye irritation:
The available data indicate that this substance is capable of causing irreversible damage to the eyes. These same effects are seen with the other ADPODS category members tested for eye irritation/corrosion.
Justification for selection of skin irritation / corrosion
endpoint:
acceptable study for the REACH-registered substance.
Justification for selection of eye irritation endpoint:
OECD Guideline, GLP study for the REACH-registered substance.
Effects on eye irritation: Irreversible damage
Justification for classification or non-classification
No classification is required for skin irritation for Reaction mass of Disodium decyl(sulphonatophenoxy)benzenesulphonate and Disodium oxybis[decylbenzenesulphonate]. For eye irritation, classification for irreversible damage to the eyes is applied (Category 1, according to CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.