Reaction product of di C8-C10, branched, C9 rich, alkylnaphthalene sulphonic acid and alkanolamine

Acute Toxicity: oral

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Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Remarks:

the tested substance is the amine part of the compound

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Guideline study (OECD 401), GLP compliant

Cross-reference

Reason / purpose for cross-reference:

read-across source

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1993

Report date:

1993

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

yes

Test type:

standard acute method

Limit test:

yes

Test material

Reference

Name:

Unnamed

Type:

Constituent

Details on test material:

- Name of test material (as cited in study report): Diisopropanolamin asymmetrisch- Lot/batch No.: 7752- Purity: 99.261% (GC)

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS- Source: DR. K. THOMAE GMBH- Age at study initiation: young adult animals- Weight at study initiation: 150 - 300 g- Fasting period before study: 16 h before administration- Housing: single housing- Diet: Kliba-Labordiaet 343, Klingenthalmuehle AG, CH-4303 Kaiseraugust, ad libitum- Water: tap water ad libitum- Acclimation period: at least 1 weekENVIRONMENTAL CONDITIONS- Temperature (°C): 20-24°C- Humidity (%): 30-70 %- Photoperiod (hrs dark / hrs light): 12/12

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

olive oil

Details on oral exposure:

VEHICLE- Justification for choice of vehicle: The test substance is insoluble in aqua bidest- Concentration in vehicle: 20 or 40 g/100 ml for the 1000 or 2000 mg/kg bw dose, respectively - Amount of vehicle: 5 ml/kg bw

Doses:

1000 and 2000 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days - Frequency of observations: Twice each workday and once on weekends- Frequency of weighing: Individual body weights shortly before application (day 0), weekly thereafter and at the end of the study.- Necropsy of survivors performed: yes- Other examinations performed: clinical signs, body weight

Statistics:

No statistics needed

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Mortality:

No mortality occured.

Clinical signs:

No symptoms were observed.

Body weight:

The expected body weight gain has been observed in the course of the study.

Gross pathology:

No abnormalities were noted at necropsy of animals sacrificed at the end of the study.

Any other information on results incl. tables

Mean body weights.

	male		female
Dose	1000 mg/kg	2000 mg/kg	1000 mg/kg	2000 mg/kg
day 0 (before application)	181	200	189	188
day 7	248	264	220	215
day 12	273	-	224	-
day 13	-	301	-	226