Registration Dossier
Registration Dossier
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EC number: 500-349-3 | CAS number: 157707-43-2 1 - 2.5 moles ethoxylated
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data from secondary source
Data source
Reference
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity study of test chemical was performed in rats.
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- ChemIDplusA TOXNET Database
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity study of test chemical was performed in rats
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- (Z)-9-Octadecen-1-ol ethoxylated
- EC Number:
- 500-016-2
- EC Name:
- (Z)-9-Octadecen-1-ol ethoxylated
- Cas Number:
- 9004-98-2
- Molecular formula:
- C58H116O21
- IUPAC Name:
- 9-Octadecen-1-ol, monoether with polyethylene glycol, (Z)-
- Details on test material:
- - Name of test material (IUPAC name): 9-Octadecen-1-ol, monoether with polyethylene glycol, (Z)-
- Common name: Polyoxyl 10 oleyl ether
- Molecular formula: C58H116O21
- Molecular weight: 312.534 g/mol
- Smiles notation: C(CCCCCCCOCCO)\C=C/CCCCCCCC
- Substance type: Organic
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 2700 mg/kg bw
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 700 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- 50% mortality was observed at dose 2700 mg/kg bw
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- the LD50 value was considered to be 2700mg/kg bw,When rats were treated with test chemical orally.
- Executive summary:
In acute oral toxicity study, rats were treated with test chemical orally.50% mortality was observed in treated rats at 2700mg/kg bw.Therefore, LD50 was considered to be 2700mg/kg bw,when rats were treated with test chemical orally.
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