Alcohols, C8-18, ethoxylated

Endpoint summary

Description of key information

Data available for the closely related read across chemicals has been reviewed to determine the acute oral toxicity of the test chemical Alcohols, C8-18, ethoxylated(157707-43-2).The studies are as mentioned below:

1.In acute oral toxicity study, rats were treated with test chemicalorally.50% mortality was observedin treated rats at 2700mg/kg bw.Therefore, LD50 was considered to be 2700mg/kg bw,when rats were treated with test chemical orally.  

2.In acute oral toxicity study, mice were treated with test chemical orally. No mortality was observedin treated mouse at 25000mg/kg bw.Therefore, LD50 was considered to be >25000mg/kg bw. When mouse were treated with test chemical orally.  

Thus, based on the above summarised studies,Alcohols, C8-18, ethoxylated(157707-43-2) and it’s closely related read across substance, it can be concluded that LD50 value is greater than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation,Alcohols, C8-18, ethoxylated(157707-43-2) cannot be classified for acute oral toxicity.Hence,based on the data available for the structurally similar and closely related read across chemical, Alcohols, C8-18, ethoxylated(157707-43-2)is not likely to be toxic atleast in the dose range of 2700->25000 mg/Kg bw.A

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

experimental data of read across substances

Justification for type of information:

Data for the target chemical is summarized based on the structurally similar read across chemicals

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

WoE report is based on two acute oral toxicity studies as-
1.and 2. Acute Oral toxicity test was carried out to study the effects of the test chemicals on rodents

GLP compliance:

not specified

Test type:

other: no data available

Limit test:

no

Species:

other: 1.rat , 2.mouse

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

no data available

Route of administration:

oral: unspecified

Vehicle:

not specified

Details on oral exposure:

no data available

Doses:

1. 2700 mg/kg bw
2. 25000 mg/kg bw

No. of animals per sex per dose:

no data available

Control animals:

not specified

Details on study design:

no data available

Statistics:

no data available

Preliminary study:

no data available

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 2 700 - <= 25 000 mg/kg bw

Based on:

test mat.

Remarks on result:

other: 1.50% mortality was observed 2. no mortality was observed

Mortality:

1.50% mortality was observed at dose 2700 mg/kg bw
2.No mortality was observed at dose 25000 mg/kg bw

Clinical signs:

other: no data available

Gross pathology:

no data available

Other findings:

no data available

Interpretation of results:

other: Not classified

Conclusions:

The test chemical Alcohols, C8-18, ethoxylated is not likely to be toxic atleast in the dose range of 2700->25000 mg/Kg bw.

Executive summary:

Data available for the closely related read across chemicals has been reviewed to determine the acute oral toxicity of the test chemical Alcohols, C8-18, ethoxylated(157707-43-2).The studies are as mentioned below:

1.In acute oral toxicity study, rats were treated with test chemical orally.50% mortality was observedin treated rats at 2700mg/kg bw.Therefore, LD50 was considered to be 2700mg/kg bw,when rats were treated with test chemical orally.  

2.In acute oral toxicity study, mice were treated with test chemical orally. No mortality was observedin treated mouse at 25000mg/kg bw.Therefore, LD50 was considered to be >25000mg/kg bw. When mouse were treated with test chemical orally.  

Thus, based on the above summarised studies,Alcohols, C8-18, ethoxylated(157707-43-2) and it’s closely related read across substance, it can be concluded that LD50 value is greater than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation,Alcohols, C8-18, ethoxylated(157707-43-2) cannot be classified for acute oral toxicity.Hence,based on the data available for the structurally similar and closely related read across chemical, Alcohols, C8-18, ethoxylated(157707-43-2)is not likely to be toxic atleast in the dose range of 2700->25000 mg/Kg bw.

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LD50

Value:

25 000 mg/kg bw

Quality of whole database:

Data is Klimisch 2 and from authoritative database

Acute toxicity: via inhalation route

Endpoint conclusion

Endpoint conclusion:

no study available

Acute toxicity: via dermal route

Endpoint conclusion

Endpoint conclusion:

no study available

Additional information

Data available for the closely related read across chemicals has been reviewed to determine the acute oral toxicity of the test chemical Alcohols, C8-18, ethoxylated(157707-43-2).The studies are as mentioned below:

1.In acute oral toxicity study, rats were treated with test chemicalorally.50% mortality was observedin treated rats at 2700mg/kg bw.Therefore, LD50 was considered to be 2700mg/kg bw,when rats were treated with test chemical orally.  

2.In acute oral toxicity study, mice were treated with test chemical orally. No mortality was observedin treated mouse at 25000mg/kg bw.Therefore, LD50 was considered to be >25000mg/kg bw. When mouse were treated with test chemical orally.  

Thus, based on the above summarised studies,Alcohols, C8-18, ethoxylated(157707-43-2) and it’s closely related read across substance, it can be concluded that LD50 value is greater than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation,Alcohols, C8-18, ethoxylated(157707-43-2) cannot be classified for acute oral toxicity.Hence,based on the data available for the structurally similar and closely related read across chemical, Alcohols, C8-18, ethoxylated(157707-43-2)is not likely to be toxic atleast in the dose range of 2700->25000 mg/Kg bw.A

Justification for classification or non-classification

Based on the above experimental studies on Alcohols, C8-18, ethoxylated(157707-43-2)and it’s closely related read across substances, it can be concluded that LD50 value is greater than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, Alcohols, C8-18, ethoxylated(157707-43-2)cannot be classified for acute oral toxicity.