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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 2017-07-11 to 2017-07-19
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
effusion method: Knudsen cell
Key result
Temp.:
20 °C
Vapour pressure:
0.005 Pa
Temp.:
25 °C
Vapour pressure:
0.007 Pa

The vapour pressure was measured in the temperature range of 120 to 170 °C. For the evaluation the vapour pressure values in the range of 135 to 160 °C were used. The melting point of the test item is in the range of 109 - 117 °C (refer to IUCLID Section 4.2 "Melting point / freezing point"), therefore, in this temperature range was technically not possible to determine a reprodusible vapour pressure.

Stage No.

Temperature, °C

Δm/Δt, mg/min

Vapour pressure, Pa

1

135

1.0430 x 10-3

2.2983 x 10-1

2

140

1.2283 x 10-3

2.7233 x 10-1

3

145

1.3306 x 10-3

2.9679 x 10-1

4

150

1.4849 x 10-3

3.3317 x 10-1

5

155

1.6014 x 10-3

3.6143 x 10-1

6

160

1.8126 x 10-3

4.1148 x 10-1

Regression data of the vapour pressure curve - Regression output

Date of measurement

Intercept

Slope

R. Squared

11 July 2017

3.5423

-1702.2269

0.9912

Conclusions:
The vapour pressure of the test item 5-sulfosalicylic acid dihydrate was calculated by extrapolation of the measured vapour pressure curve for the temperatures 20 and 25 °C:
Vapour pressure at 20 °C: 5.441E-3 Pa
Vapour pressure at 25 °C: 6.808E-3 Pa
Executive summary:

A study was conducted according to OECD TG 104, Regulation (EC) No 440/2008 method A.4 and OPPTS 830.7950 to determine the vapour pressure of the test item. The vapour pressure of the test item was determined at temperatures between 120 and 170 °C using the effusion method (Knudsen cell). For the evaluation the vapour pressure values in the range of 135 to 160 °C were used. The vapour pressure of the test item was calculated by extrapolation of the measured vapour pressure curve for the temperatures 20 and 25 °C. The vapour pressure was calculated to be 5.441E-3 Pa at 20 °C and 6.808E-3 Pa at 25 °C, respectively.

Description of key information

The vapour pressure of the test item was calculated to be 5.441E-3 Pa at 20 °C and 6.808E-3 Pa at 25 °C, respectively.

Key value for chemical safety assessment

Vapour pressure:
0.005 Pa
at the temperature of:
20 °C

Additional information

A study (reference 4.6-1) was conducted according to OECD TG 104, Regulation (EC) No 440/2008 method A.4 and OPPTS 830.7950 to determine the vapour pressure of the test item. The vapour pressure of the test item was determined at temperatures between 120 and 170 °C using the effusion method (Knudsen cell). For the evaluation the vapour pressure values in the range of 135 to 160 °C were used. The vapour pressure of the test item was calculated by extrapolation of the measured vapour pressure curve for the temperatures 20 and 25 °C. The vapour pressure was calculated to be 5.441E-3 Pa at 20 °C and 6.808E-3 Pa at 25 °C, respectively.