Registration Dossier

Administrative data

Description of key information

Acute oral toxicity:

Acute oral toxicity test was performed from Dictionary of Environmentally Important Chemicals, 1999 in rats at 333 mg/kg dose concentration After treatment it was considered that the LD 50 value for ammonium molybdate (13106-76-8) was considered to be 333 mg/kg in rats.

Acute dermal toxicity:

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from authoritative handbook.
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Data is from authoritative handbook.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no
Specific details on test material used for the study:
- Name of test material (as cited in study report): ammonium molybdate(VI)
- Molecular formula: MoO4.2H4N
- Molecular weight: 196.0132 g/mol
- Smiles notation: [Mo](=O)(=O)([O-])[O-].[NH4+].[NH4+]
- InChl: 1S/Mo.2H3N.4O/h;2*1H3;;;;/q;;;;;2*-1/p+2
- Substance type: Inorganic
- Physical state: Solid
Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data available
Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
333 mg/kg
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available
Sex:
not specified
Dose descriptor:
LD50
Effect level:
333 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50 % mortality observed
Mortality:
No data available
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available

No data available

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The LD 50 value for acute oral toxicity for ammonium molybdate (13106-76-8) was considered to be 333 mg/kg in rats.
Executive summary:

Acute oral toxicity test was performed on rats at 333 mg/kg dose concentration.

After treatment it was considered that the LD 50 value for ammonium molybdate (13106-76-8) was considered to be 333 mg/kg in rats.

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
333 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

In different studies, ammonium molybdate (13106-76-8) has been investigated for potential of acute oral toxicity to a greater or lesser extent. The studies are based on in vivo experiments in rats and guinea pig for target chemical ammonium molybdate (13106-76-8)

Acute oral toxicity test was performed from Dictionary of Environmentally Important Chemicals, 1999 in rats at 333 mg/kg dose concentration After treatment it was considered that the LD 50 value for ammonium molybdate (13106-76-8) was considered to be 333 mg/kg in rats.

Supported study to the above key study the acute toxicity test was performed on guinea pig from Toxline,2017 at 0.50-0.75 gram (500 -750 mg) concentration. Some clinical symptoms were observed before autopsy and after death stomach full or containing a bloody, greenish pap like substance, the large intestine almost always full or soft, bloody, diarrheic fecal matter, small discolored spots in the liver approximately 4 millimeters in diameter; and Tardieu's spots in the lungs were observed. From the experiment, the LD 100 value for ammonium molybdate (13106-76-8) was considered to be 500-750 gram to guinea pig.

Thus, based on the above studies on ammonium molybdate (13106-76-8), it can be concluded that LD50 value is lesser than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, ammonium molybdate (13106-76-8) can be considered “classified in acute category 4” for acute oral toxicity.

Justification for classification or non-classification

Based on the above studies on ammonium molybdate (13106-76-8), it can be concluded that LD50 value is lesser than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, ammonium molybdate (13106-76-8) can be considered “classified in acute category 4” for acute oral toxicity.