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EC number: 236-031-3 | CAS number: 13106-76-8
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity:
Acute oral toxicity test was performed from Dictionary of Environmentally Important Chemicals, 1999 in rats at 333 mg/kg dose concentration After treatment it was considered that the LD 50 value for ammonium molybdate (13106-76-8) was considered to be 333 mg/kg in rats.
Acute dermal toxicity:
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative handbook.
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Data is from authoritative handbook.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): ammonium molybdate(VI)
- Molecular formula: MoO4.2H4N
- Molecular weight: 196.0132 g/mol
- Smiles notation: [Mo](=O)(=O)([O-])[O-].[NH4+].[NH4+]
- InChl: 1S/Mo.2H3N.4O/h;2*1H3;;;;/q;;;;;2*-1/p+2
- Substance type: Inorganic
- Physical state: Solid - Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 333 mg/kg
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 333 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50 % mortality observed
- Mortality:
- No data available
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The LD 50 value for acute oral toxicity for ammonium molybdate (13106-76-8) was considered to be 333 mg/kg in rats.
- Executive summary:
Acute oral toxicity test was performed on rats at 333 mg/kg dose concentration.
After treatment it was considered that the LD 50 value for ammonium molybdate (13106-76-8) was considered to be 333 mg/kg in rats.
Reference
No data available
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 333 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In different studies, ammonium molybdate (13106-76-8) has been investigated for potential of acute oral toxicity to a greater or lesser extent. The studies are based on in vivo experiments in rats and guinea pig for target chemical ammonium molybdate (13106-76-8)
Acute oral toxicity test was performed from Dictionary of Environmentally Important Chemicals, 1999 in rats at 333 mg/kg dose concentration After treatment it was considered that the LD 50 value for ammonium molybdate (13106-76-8) was considered to be 333 mg/kg in rats.
Supported study to the above key study the acute toxicity test was performed on guinea pig from Toxline,2017 at 0.50-0.75 gram (500 -750 mg) concentration. Some clinical symptoms were observed before autopsy and after death stomach full or containing a bloody, greenish pap like substance, the large intestine almost always full or soft, bloody, diarrheic fecal matter, small discolored spots in the liver approximately 4 millimeters in diameter; and Tardieu's spots in the lungs were observed. From the experiment, the LD 100 value for ammonium molybdate (13106-76-8) was considered to be 500-750 gram to guinea pig.
Thus, based on the above studies on ammonium molybdate (13106-76-8), it can be concluded that LD50 value is lesser than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, ammonium molybdate (13106-76-8) can be considered “classified in acute category 4” for acute oral toxicity.
Justification for classification or non-classification
Based on the above studies on ammonium molybdate (13106-76-8), it can be concluded that LD50 value is lesser than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, ammonium molybdate (13106-76-8) can be considered “classified in acute category 4” for acute oral toxicity.
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