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Description of key information

Skin sensitization

From the British medical journal 15 November 1975, patch test was performed on 50 patient using Al-test strips to the pads of which were applied the metal allergens. Ammonium molybdate was placed on back and held in place with hypoallergic tape. Patch was kept for 3 days and again the test site was examined on seventh day. No sensitivity was observed for ammonium molybdate, therefore ammonium molybdate (13106-76-8) was determined to be non-sensitizing to human after exposure.

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records
Reference
Endpoint:
skin sensitisation, other
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from peer reviewed journal.
Justification for type of information:
Data is from peer reviewed journal.
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To observed the effect of ammonium molybdate which was used in patch test to 50 patient using Al-test strips.
GLP compliance:
not specified
Type of study:
patch test
Specific details on test material used for the study:
- Name of test material (as cited in study report): ammonium molybdate(VI)
- Molecular formula: MoO4.2H4N
- Molecular weight: 196.0132 g/mol
- Smiles notation: [Mo](=O)(=O)([O-])[O-].[NH4+].[NH4+]
- InChl: 1S/Mo.2H3N.4O/h;2*1H3;;;;/q;;;;;2*-1/p+2
- Substance type: Inorganic
- Physical state: Solid
Species:
other: Human
Strain:
other: not applicable
Sex:
not specified
Details on test animals and environmental conditions:
No data available
Route:
epicutaneous, open
Vehicle:
not specified
Concentration / amount:
1%
Day(s)/duration:
3 days
No. of animals per dose:
50 patient
Details on study design:
MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: 1
- Exposure period: 3 days
- Test groups: 50 patient
- Site: on the back and held in place with hypoallergic tape
- Frequency of applications: 1
- Duration: 3 days
- Concentrations: 1%
Challenge controls:
No data available
Positive control substance(s):
not specified
Reading:
other: induction
Group:
test group
Dose level:
1% of ammonium molybdate
Total no. in group:
50
Clinical observations:
No reaction was observed
Remarks on result:
no indication of skin sensitisation

score used for observation

·         + erythema

·         ++ vesicular rash confined to area of patch

-      +++- extensive eczematous reaction beyond area of patch

Interpretation of results:
other: Not sensitizing
Conclusions:
The ammonium molybdate (13106-76-8) was determined to be non-sensitizing to human after exposure.
Executive summary:

Patch test was performed on 50 patient using Al-test strips to the pads of which were applied the metal allergens. Ammonium molybdate was placed on back and held in place with hypoallergic tape. Patch was kept for 3 days and again the test site was examined on seventh day.

No sensitivity was observed for ammonium molybdate, therefore ammonium molybdate (13106-76-8) was considered to be non-sensitizing to human after exposure.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

In different studies, ammonium molybdate (13106-76-8) has been investigated for potential of skin sensitization to a greater or lesser extent. The studies are based on in vivo experiments in human for target chemical ammonium molybdate (13106-76-8).

From the British medical journal 15 November 1975, patch test was performed on 50 patient using Al-test strips to the pads of which were applied the metal allergens. Ammonium molybdate was placed on back and held in place with hypoallergic tape. Patch was kept for 3 days and again the test site was examined on seventh day. No sensitivity was observed for ammonium molybdate, therefore ammonium molybdate (13106-76-8) was determined to be non-sensitizing to human after exposure.

Supported to the above key study skin sensitization test was performed in humans from MAK Collection for Occupational Health and Safety, 2012. The ammonium molybdate was applied to 63 patients during dental prostheses. Concentration of chemical was 1% after treatment it was observed that the ammonium molybdate (13106-76-8) was determined to be not sensitizing to human.

From the same reference, ammonium molybdate was applied to 50 patients for joint prostheses. Concentration of chemical was 1% after treatment it was observed that the ammonium molybdate (13106-76-8) was found to be not sensitizing to human.

Ammonium molybdate was applied to 128 patients for hip prostheses from the above same reference. Concentration of chemical was 1% of ammonium molybdate and after treatment it was observed that the ammonium molybdate (13106-76-8) was determined to be sensitizing to human.

Thus based on key and supporting data, it can be considered that ammonium molybdate (13106-76-8) was not a skin sensitizer supported by the majority of the above studies. Thus comparing the above annotations with the criteria of CLP regulation, ammonium molybdate (13106-76-8) can be considered as not classified for skin sensitization.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

Based on key and supporting data, it can be considered that ammonium molybdate (13106-76-8) was not a skin sensitizer supported by the majority of the above studies. Thus comparing the above annotations with the criteria of CLP regulation, ammonium molybdate (13106-76-8) can be considered as not classified for skin sensitization.