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Registration Dossier
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EC number: 200-464-6 | CAS number: 60-24-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: early study report; only short study description
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 964
- Report date:
- 1964
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standards
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-mercaptoethanol
- EC Number:
- 200-464-6
- EC Name:
- 2-mercaptoethanol
- Cas Number:
- 60-24-2
- Molecular formula:
- C2H6OS
- IUPAC Name:
- 2-sulfanylethan-1-ol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Heigl
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 200, 400, 800, 1600 cmm/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- Concentrations given were 2 - 20% in water; observation period: 7 days
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 336 mg/kg bw
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 300 other: cmm/kg
- Remarks on result:
- other: original value
- Mortality:
- 1600 cmm/kg: 5/5 after 7 days (20% concentration); 800 cmm/kg: 5/5 after 7 days (4% concentration); 400 cmm/kg: 4/5 after 7 days (4% concentration), 200 cmm/kg: 1/5 after 7 days (2% concentration)
- Clinical signs:
- other: Jumping, running, rolling behavior; tonic-clonic seizure; cyanosis; recovery after 4-6 d.
- Gross pathology:
- Sacrificed animals: nothing abnormal detected.
Applicant's summary and conclusion
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