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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: early study report; only short study description

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1964
Report date:
1964

Materials and methods

Principles of method if other than guideline:
according to BASF-internal standards
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-mercaptoethanol
EC Number:
200-464-6
EC Name:
2-mercaptoethanol
Cas Number:
60-24-2
Molecular formula:
C2H6OS
IUPAC Name:
2-sulfanylethan-1-ol

Test animals

Species:
rat
Strain:
other: Heigl
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
200, 400, 800, 1600 cmm/kg
No. of animals per sex per dose:
5
Control animals:
not specified
Details on study design:
Concentrations given were 2 - 20% in water; observation period: 7 days

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LD50
Effect level:
336 mg/kg bw
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 300 other: cmm/kg
Remarks on result:
other: original value
Mortality:
1600 cmm/kg: 5/5 after 7 days (20% concentration); 800 cmm/kg: 5/5 after 7 days (4% concentration); 400 cmm/kg: 4/5 after 7 days (4% concentration), 200 cmm/kg: 1/5 after 7 days (2% concentration)
Clinical signs:
other: Jumping, running, rolling behavior; tonic-clonic seizure; cyanosis; recovery after 4-6 d.
Gross pathology:
Sacrificed animals: nothing abnormal detected.

Applicant's summary and conclusion