Registration Dossier
Registration Dossier
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EC number: 235-473-4 | CAS number: 12239-15-5
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- data is from RTECS
Data source
Reference
- Reference Type:
- secondary source
- Title:
- RTECS - DR6040000
- Author:
- Registry of Toxic Effects of Chemical Substances (RTECS)
- Year:
- 1 997
- Bibliographic source:
- RTECS - DR6040000, Registry of Toxic Effects of Chemical Substances (RTECS), last updated 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To assess the eye irritation potential of 2,5-dichloro-4-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzene-1-sulfonic acid in rabbits
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,5-dichloro-4-(3-methyl-5-oxo-2-pyrazolin-1-yl)benzenesulphonic acid
- EC Number:
- 201-541-7
- EC Name:
- 2,5-dichloro-4-(3-methyl-5-oxo-2-pyrazolin-1-yl)benzenesulphonic acid
- Cas Number:
- 84-57-1
- Molecular formula:
- C10H8Cl2N2O4S
- IUPAC Name:
- 2,5-dichloro-4-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzene-1-sulfonic acid
- Test material form:
- solid
- Details on test material:
- Name of the test chemical: 2,5-dichloro-4-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzene-1-sulfonic acid
Molecular Formula:C10H8Cl2N2O4S
Molecular Weight: 323.555 g/mol
InChI: 1S/C10H8Cl2N2O4S/c1-5-2-10(15)14(13-5)8-3-7(12)9(4-6(8)11)19(16,17)18/h3-4H,2H2,1H3,(H,16,17,18)
Substance Type: Organic
Physical State: Solid
Constituent 1
- Specific details on test material used for the study:
- Name of the test chemical: 2,5-dichloro-4-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzene-1-sulfonic acid
Molecular Formula:C10H8Cl2N2O4S
Molecular Weight: 323.555 g/mol
InChI: 1S/C10H8Cl2N2O4S/c1-5-2-10(15)14(13-5)8-3-7(12)9(4-6(8)11)19(16,17)18/h3-4H,2H2,1H3,(H,16,17,18)
Substance Type: Organic
Physical State: Solid
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- no data available
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 500mg
- Duration of treatment / exposure:
- 24hours
- Observation period (in vivo):
- 24 hours
- Duration of post- treatment incubation (in vitro):
- no data available
- Number of animals or in vitro replicates:
- no data available
- Details on study design:
- no data availabled
Results and discussion
In vitro
- Other effects / acceptance of results:
- no data available
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- Mikd signs of irritation were observed
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- Mild irritation effects were observed in rabbit eyes after 24 hours of exposure to 2,5-dichloro-4-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzene-1-sulfonic acid.Hence, 2,5-dichloro-4-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzene-1-sulfonic acid can be considered to be irritating to eyes.
- Executive summary:
An eye irritation study was conducted to evaluate irritation potential of 2,5-dichloro-4-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzene-1-sulfonic acid.500 mg of the test chemical was instilled into the eyes of rabbits and effects were observed for 24 hours. Mild irritation effects were observed in rabbit eyes after 24 hours of exposure to 2,5-dichloro-4-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzene-1-sulfonic acid.Hence, 2,5-dichloro-4-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzene-1-sulfonic acid can be considered to be irritating to eyes.
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