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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from authoritative database

Data source

Referenceopen allclose all

Reference Type:
other: authoritative database
Title:
Acute oral toxicity study of 1-Phenyl-3-methyl-5-aminopyrazole(1131-18-6) in rats
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
Chemidplus Database,U.S. National Library of Medicine,2017
Reference Type:
review article or handbook
Title:
RTECS NUMBER : UQ4990000
Author:
RTECS database
Year:
2017
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances),2017

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as below
Principles of method if other than guideline:
The acute toxicity study of 3-methyl-1-phenylpyrazol-5-ylamine(1131-18-6) was performed in rat by oral route.
GLP compliance:
not specified
Test type:
other: no data available
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid
Details on test material:
- Name of test material: 3-methyl-1-phenylpyrazol-5-ylamine
- Molecular formula: C10H11N3
- Molecular weight: 173.21744 g/mole
- Substance type: Organic
- Physical state: Solid
Specific details on test material used for the study:
- Name of test material: 3-methyl-1-phenylpyrazol-5-ylamine
- Molecular formula: C10H11N3
- Molecular weight: 173.21744 g/mole
- Substance type: Organic
- Physical state: Solid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
2500 mg/kg
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
2 500 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50 % mortality observed
Mortality:
50 % mortality was observed in treated rats at 2500 mg/kg bw
Clinical signs:
Changes in motor activity were observed.
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: not classified
Conclusions:
LD50 was considered to be 2500 mg/kg bw,when rat were treated with 3-methyl-1-phenyl-1H-pyrazol-5-amine(1131-18-6) orally.
Executive summary:

In a acute oral toxicity study, rats were treated with 3-methyl-1-phenyl-1H-pyrazol-5-amine (1131-18-6) in the concentration of 2500 mg/kg bw orally. 50 % mortality was observed in treated rats at 2500 mg/kg bw. Changes in motor activity were observed. Therefore, LD50 was considered to be 2500 mg/kg bw,when rat were treated with 3-methyl-1-phenyl-1H-pyrazol-5-amine (1131-18-6) orally.