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EC number: 241-680-0 | CAS number: 17691-19-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- data is from experimental reports
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- The objective of the study was to determine the cutaneous toxicity of Sodium 4-chloro-3-nitrobenzenesulphonate
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium 4-chloro-3-nitrobenzenesulphonate
- EC Number:
- 241-680-0
- EC Name:
- Sodium 4-chloro-3-nitrobenzenesulphonate
- Cas Number:
- 17691-19-9
- Molecular formula:
- C6H3ClNNaO5S
- IUPAC Name:
- sodium 4-chloro-3-nitrobenzene-1-sulfonate
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of the test material: Sodium 4-chloro-3-nitrobenzenesulphonate
- IUPAC Name : sodium 4-chloro-3-nitrobenzene-1-sulfonate
- Molecular formula: C6H4ClNO5SNa
- Molecular weight: 259.601 g/mol
- Smiles: S(=O)(=O)([O-])c1cc([N+]([O-])=O)c(Cl)cc1.[Na+]
- InChI: 1S/C6H4ClNO5S.Na/c7-5-2-1-4(14(11,12)13)3-6(5)8(9)10;/h1-3H,(H,11,12,13);/q;+1/p-1
- Substance type: Organic
- Physical state: Solid powder (Off white to pale yellow)
Constituent 1
- Specific details on test material used for the study:
- - Name of the test material: Sodium 4-chloro-3-nitrobenzenesulphonate
- IUPAC Name : sodium 4-chloro-3-nitrobenzene-1-sulfonate
- Molecular formula: C6H4ClNO5SNa
- Molecular weight: 259.601 g/mol
- Smiles: S(=O)(=O)([O-])c1cc([N+]([O-])=O)c(Cl)cc1.[Na+]
- InChI: 1S/C6H4ClNO5S.Na/c7-5-2-1-4(14(11,12)13)3-6(5)8(9)10;/h1-3H,(H,11,12,13);/q;+1/p-1
- Substance type: Organic
- Physical state: Solid powder (Off white to pale yellow)
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Sex: Male and female
- Source: Hacking and Churchill Limited, Huntingdon, England
- Age at study initiation: no data available
- Weight at study initiation:
- Housing:individually in stainless steel cages
- Diet (e.g. ad libitum): Ssniff K Pallets, ad libitum (Ssniff Experimental animal diet GmbH, 4770 Soest)
- Water (e.g. ad libitum): Drinking water ad libitum from plastic bottles with steel nipples
- Acclimation period: no data available
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 deg C
- Humidity (%): 60%
- Air changes (per hr): no data available
- Photoperiod (hrs dark / hrs light):12-hour light-dark rhythm
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- not specified
- Amount / concentration applied:
- 500 mg of the substance were dissolved with 0.1 ml of double-distilled water
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- (1h), 24, 48, 72 hours and, if necessary, 7 days after treatment for erythema on the cutaneous
- Number of animals:
- 3 (1 male and 2 female)
- Details on study design:
- TEST SITE
- Area of exposure: dorsal and lateral parts of the trunk
- % coverage: 2.5 × 2.5 cm gauze swab Transfilmine. Combined Fixiarl
- Type of wrap if used: Transfilmine. Combined Fixiarl
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: After the end of the exposure time, the bare skin areas were rinsed with water and soap and dried.
OBSERVATION TIME POINTS
(indicate if minutes, hours or days) : The observation period lasted 72 hours or 7 days;
Each animal was observed at 1h, 24, 48, 72 hours and, if necessary, 7 days after treatment for erythema and edema
SCORING SYSTEM:
- Method of calculation: Skin lesions were scored according to the following OECD Guidelines on testing materials where appropriate responses were recorded.
Results and discussion
In vitro
- Other effects / acceptance of results:
- no data available
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- All rabbits in which the test substance was applied to the skin, negative effects were observed
Any other information on results incl. tables
Table: Acute Dermal Irritation in Rabbits
(According to OECD 404 Guidelines)
Animal number |
Sex |
Erythema |
Edema |
Skin fold thickness |
||||||||
1h |
24h |
48h |
72h |
7 days |
1h |
24h |
48h |
72h |
7 days |
|
||
135 |
Male |
0 |
0 |
0 |
0 |
- |
0 |
0 |
0 |
0 |
- |
Not measured |
194 |
Female |
0 |
0 |
0 |
0 |
- |
0 |
0 |
0 |
0 |
- |
Not measured |
195 |
Female |
0 |
0 |
0 |
0 |
- |
0 |
0 |
0 |
0 |
- |
Not measured |
Mean |
0 |
0 |
0 |
0 |
- |
0 |
0 |
0 |
0 |
- |
|
Applicant's summary and conclusion
- Interpretation of results:
- other: Not irritating
- Conclusions:
- Negative effects were observed in all the rabbits after 72 hours of observation. The mean irritation score was 0.0 after 72 hours. Hence, Sodium 4-chloro-3-nitrobenzenesulphonate can be considered to be not irritating to skin.
- Executive summary:
The objective of the study was to determine the cutaneous toxicity of Sodium 4-chloro-3-nitrobenzenesulphonate. The study was performed as per OECD 404 Guidelines. 3(1 male and 2 female) New Zealand White rabbits were used. For the determination of the acute irritative effect, the dorsal and lateral parts of the trunk were shaved 16-24 hours prior to treatment with an electric cutting machine. The test substance was administered as an 83% aqueous solution. In addition, 500 mg of the substance were dissolved with 0.1 ml of double-distilled water. The aqueous solution was spread on a flax of about 6 cm 2 on the gastric dorsal skin, covered with a 2.5 × 2.5 cm gauze swab Transfilmine Combined Fixiarl for four hours.During the exposure time, the rabbits were housed individually in separate cages. After the end of the exposure time, the bare skin areas were rinsed with water and soap and dried. The observation period lasted 72 hours or 7 days. Each animal was observed at 1h, 24, 48, 72 hours and, if necessary, 7 days after treatment for erythema and edema. Skin lesions were scored according to the following OECD Guidelines on testing materials where appropriate responses were recorded.
Negative effects were observed in all the rabbits after 72 hours of observation. The mean irritation score was 0.0 after 72 hours. Hence, Sodium 4-chloro-3-nitrobenzenesulphonate can be considered to be not irritating to skin.
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