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Classification & Labelling & PBT assessment

PBT assessment

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Administrative data

PBT assessment: overall result

PBT status:
the substance is not PBT / vPvB

Classification of sodium 4-chloro-3-nitrobenzene-1-sulfonate for effects in the environment:


The chemical sodium 4-chloro-3-nitrobenzene-1-sulfonate (CAS no. 17691-19-9) is used as a dye intermediate for manufacturing of several dyes and fine chemicals.The aim was to assess whether the PBT criterion within Annex XIII was fulfilled for sodium 4-chloro-3-nitrobenzene-1-sulfonate. The PBT criterion was herein assessed based on experimental data in conjunction with standardized environmental fate models. Here follows a description of the PBT assessment.


Persistence assessment

The tested substance fulfils the P criterion within Annex XIII based on the assessment that here follows:


Biotic degradation

Biodegradability of test chemical Sodium 4-chloro-3-nitrobenzenesulphonate (CAS no.17691 -19 -9) was estimated by using OECD QSAR tool box v3.3 by considering six closest read across chemicals with log Kow as primary descriptor. The test chemical 2-aminotoluene-4-sulphonic acid undergoes 0.3% biodegradation by considering BOD as parameter and microorganisms as inoculum in 28 days. On the basis of this percent biodegradability value it can be concluded that test chemical Sodium 4-chloro-3-nitrobenzenesulphonate is not readily biodegradable.


Experimental results from the read across substances (CAS: 2217-82-5 and 127-68-4) also indicate that they are not readily biodegradable.


As the half-life value of chemical sodium 4-chloro-3-nitrobenzene-1-sulfonate is not known and only predicted data is available for the substance, it has been concluded that sodium 4-chloro-3-nitrobenzene-1-sulfonateis likely to be persistent (P) in nature.

Bioaccumulation assessment

The tested substance does not fulfil the B criterion within Annex XIII based on the assessment that here follows:


Theestimated BCF value from authoritative database was determined to be in the range from 0.5 to 3.58, respectively and theoctanol water partition coefficient of the test chemical ranges was estimated to be -2.49 respectively, which is less than the threshold of 4.5. If this chemical is released into the aquatic environment, there should be a low risk for the chemical to bioaccumulate in fish and food chains.


Toxicity assessment

The tested substance does not fulfil the T criterion within Annex XIII based on the assessment that here follows:



The tested chemical is regarded to be not classified for carcinogenicity, mutagenicity and reprotoxicity, Further, there is no evidence of chronic toxicity, as identified by the classifications STOT (repeated exposure), category 1(oral, dermal, inhalation of gases/vapours, inhalation of dust/mist/fume) or category 2 (oral, dermal, inhalation of gases/vapours, inhalation of dust/mist/fume).


Aquatic organisms

All of the available short-term eco-toxicity estimations for invertebrates and algae for the substance indicates the LC50/EC50 value to be in the range 150.137 to 161.105 mg/L. These value suggest that the substance is not likely to be hazardous to Aquatic organisms at environmentally relevant concentrations and can be considered to be ‘not classified’ as per the CLP regulation.


There are no available long-term toxicity evaluations for sodium 4-chloro-3-nitrobenzene-1-sulfonate. By speculation, long-term NOEC for aquatic organisms were not expected for the substance at concentration below 0.01 mg/L based on the data mentioned above.


The chemical was therefore not considered as hazardous to aquatic environments as per the criteria set out in Annex XIII.




Based on critical, independent and collective evaluation of information summarized herein, the tested compound fulfils the P criterion but does not fulfil the B and T criterion and has therefore not been classified as a PBT compound within Annex XIII.