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No toxicokinetic, metabolism or distribution studies were identified for 2 -methylpropane-2-thiol.

Simple thiols are expected to be metabolized via several different pathways in mammalian systems that include: S-methylation, resulting in a methyl thioether that would undergo S-oxidation; reaction with glutathione to form mixed disulfides (the likely form in circulation); and, especially for the low molecular weight thiols, oxidative desulfuration to yield CO and SO4. (Mattia and Renwick, 2000).