Registration Dossier
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EC number: 200-890-2 | CAS number: 75-66-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
One key study was identified to evaluate the dermal irritation potential of 2-methylpropane-2-thiol. The test material was not identified as a dermal irritant in rabbits following 4 hour occlusive exposure. No key data examining eye irritation was available for 2-methylpropane-2-thiol; however a read-across study from the structural analogue, propane-1-thiol, was identified. Propane-1-thiol was identified as a slight ocular irritant in rabbits. No key data examining respiratory irritation was available for 2-methylpropane-2-thiol; however acute inhalation data from studies in rats and mice indicates that 2-methylpropane-2-thiol is not a respiratory irritant.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin Irritation
A key primary dermal irritation study (Latven, 1976; Klimisch score = 2) was identified to evaluate the skin irritation potential of 2-methylpropane-2-thiol. In this study, six albino rabbits were dermally exposed to 0.5 mL 2-methylpropane-2-thiol under occlusive wrap for 4 hours. The animals were subsequently observed for a period of 3 days. There was no evidence of dermal irritation at any of the treatment sites and the overall irritation score (24, 48, and 72 hour mean) was 0. 2-methylpropane-2-thiol was not considered to be irritating to the skin of rabbits.
Eye Irritation
No key data were available to evaluate the eye irritation potential of 2 -methylpropane-2-thiol. However, a read across primary eye irritation study (Moon, 1981c; Klimisch score = 2) with rabbits was identified to evaluate the eye irritation potential of propane-1-thiol, a structural analog of 2 -methylpropane-2-thiol. Although this study was conducted prior to adoption of GLP and guidelines, there was sufficient detail to consider it comparable to OECD TG405. A 0.1 mL dose was instilled into one eye of six rabbits, the eye was held closed for 4 seconds and irritation was scored at 1, 24, 48 hours and 7 days. At the 1-hour scoring interval, five of six animals showed slight to dark redness, discharge was observed in four, chemosis was observed in three and one animal had a lesion. At the 24-hour interval, three animals had returned to normal and remained normal through study termination (day 7). Two of three affected animals showed redness through the 4-day scoring interval. One of these animals (lesion-bearing) had chemosis through the 72-hour reading. The remaining animal had redness that resolved after the 24-hour reading. By the 7-day observation period, the treated eyes of all animals were normal. The mean Draize score was 3.3/110. 2-methylpropane-2-thiol was considered to be slightly irritating to the eyes.
Respiratory Tract Irritation
There are no respiratory irritation data available for 2-methylpropane-2-thiol. However, acute inhalation toxicity data available from studies conducted in rats (Daly, 1986) and mice (Fairchild and Stokinger, 1958) appear to indicate that exposure to 2-methylpropane-2-thiol does not cause respiratory irritation.
Effects on eye irritation: slightly irritating
Justification for classification or non-classification
2-methylpropane-2-thiol does not meet the criteria for classification and labelling as a skin irritant under EU Dangerous Substances Directive 67/548/EEC or CLP EU Regulation 1272/2008.
2-methylpropane-2-thiol does not meet the criteria for classification and labelling as an eye irritant as defined by EU Dangerous Substances Directive 67/548/EEC or CLP EU Regulation 1272/2008 based on read-across to studies of structural analogues which were not irritating to the eyes of rabbits.
2-methylpropane-2-thiol does not meet the criteria for classification and labelling as a respiratory irritant under EU Dangerous Substances Directive 67/548/EEC or CLP EU Regulation 1272/2008.
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