Registration Dossier
Registration Dossier
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EC number: 223-954-1 | CAS number: 4133-34-0
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from safety assessment report.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- IUCLID Dataset - 4-Methylanisole
- Author:
- European Chemicals Bureau (ECB)
- Year:
- 2 000
- Bibliographic source:
- IUCLID Dataset - 4-Methylanisole European Chemicals Bureau (ECB) 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- To evaluate ocular irritation potential of 4-methylanisole on rabbits
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-methylanisole
- EC Number:
- 203-253-7
- EC Name:
- 4-methylanisole
- Cas Number:
- 104-93-8
- Molecular formula:
- C8H10O
- IUPAC Name:
- 1-methoxy-4-methylbenzene
- Details on test material:
- IUPAC name:4-methylanisole
commen name:1-Methoxy-4-methylbenzene
Molecular formula:C8H10O
Molecular weight :122.166g/mol
Substance type:organic
InChI: 1S/C8H10O/c1-7-3-5-8(9-2)6-4-7/h3-6H,1-2H3
Smiles :COc1ccc(C)cc1
Constituent 1
- Specific details on test material used for the study:
- IUPAC name:4-methylanisole
commen name:1-Methoxy-4-methylbenzene
Molecular formula:C8H10O
Molecular weight :122.166g/mol
Substance type:organic
InChI: 1S/C8H10O/c1-7-3-5-8(9-2)6-4-7/h3-6H,1-2H3
Smiles :COc1ccc(C)cc1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- No data available
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- Not specified
- Duration of treatment / exposure:
- Not specified
- Observation period (in vivo):
- Not specified
- Details on study design:
- Not specified
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No indication of ocular reaction
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- 4-methylanisole was evaluated for its eye irritation potential on rabbits. 4-methylanisole produced no ocular reactions were noted . 4-methylanisole is considered to be not irritating to rabbit eye.
- Executive summary:
4-methylanisole was used as test material for evaluation of its ocular irritation potential on rabbits , according toOECD Guide–line 405 "Acute Eye Irritation/Corrosion"4-methylanisole was evaluated for its eye irritation potential on rabbits. 4-methylanisole produced no ocular reactions were noted . 4-methylanisole is considered to be not irritating to rabbit eye.
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