Registration Dossier

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from safety assessment report.

Data source

Reference
Reference Type:
secondary source
Title:
IUCLID Dataset - 4-Methylanisole
Author:
European Chemicals Bureau (ECB)
Year:
2000
Bibliographic source:
IUCLID Dataset - 4-Methylanisole European Chemicals Bureau (ECB) 2000

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Principles of method if other than guideline:
To evaluate ocular irritation potential of 4-methylanisole on rabbits
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
IUPAC name:4-methylanisole
commen name:1-Methoxy-4-methylbenzene
Molecular formula:C8H10O
Molecular weight :122.166g/mol
Substance type:organic
InChI: 1S/C8H10O/c1-7-3-5-8(9-2)6-4-7/h3-6H,1-2H3
Smiles :COc1ccc(C)cc1
Specific details on test material used for the study:
IUPAC name:4-methylanisole
commen name:1-Methoxy-4-methylbenzene
Molecular formula:C8H10O
Molecular weight :122.166g/mol
Substance type:organic
InChI: 1S/C8H10O/c1-7-3-5-8(9-2)6-4-7/h3-6H,1-2H3
Smiles :COc1ccc(C)cc1

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
No data available

Test system

Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
Not specified
Duration of treatment / exposure:
Not specified
Observation period (in vivo):
Not specified
Details on study design:
Not specified

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No indication of ocular reaction

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
4-methylanisole was evaluated for its eye irritation potential on rabbits. 4-methylanisole produced no ocular reactions were noted . 4-methylanisole is considered to be not irritating to rabbit eye.
Executive summary:

4-methylanisole was used as test material for evaluation of its ocular irritation potential on rabbits , according toOECD Guide–line 405 "Acute Eye Irritation/Corrosion"4-methylanisole was evaluated for its eye irritation potential on rabbits. 4-methylanisole produced no ocular reactions were noted . 4-methylanisole is considered to be not irritating to rabbit eye.