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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer-reviewed journal

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Fragrance raw materials monographs: 4-(p-methoxyphenyl) butan-2-one
Author:
D. L. J. Opdyke
Year:
1974
Bibliographic source:
Food and Cosmetics Toxicology. 12, 929, 1974
Reference Type:
publication
Title:
The FEMA GRAS assessment of aromatic substituted secondary alcohols, ketones, and related esters used as flavor ingredients
Author:
T.B. Adams ,M.M. McGowen , M.C. Williams , S.M. Cohen , V.J. Feron ,J.I. Goodman , L.J. Marnett , I.C. Munro , P.S. Portoghese ,R.L. Smith , W.J. Waddell
Year:
2007
Bibliographic source:
Food and Chemical Toxicology 45 (2007) 171–201
Reference Type:
other: Authoritative database
Title:
Acute oral toxicity study of 4-(4-methoxyphenyl)butan-2-one (104-20-1) in Rat
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
Chemidplus Database,U.S. National Library of Medicine,2017

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute oral toxicity test for substance 4-(4-methoxyphenyl)butan-2-one (104-20-1) was performed in rats.
GLP compliance:
not specified
Test type:
other: No data available
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material: 4-(4-Methoxyphenyl)butan-2-one (Anisyl acetone)
- IUPAC name: 4-(4-methoxyphenyl)butan-2-one
- Molecular formula: C11H14O2
- Molecular weight: 178.23 g/mol
- Substance type: Organic
Specific details on test material used for the study:
- Name of test material (as cited in study report):4-(p-methoxyphenyl)butan-2-one
- Molecular formula :C11H14O2
- Molecular weight :178.23 g/mole
- Substance type:Organic
- Physical state:Liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality was observed in treated rats at 5000 mg/kg bw
Mortality:
No mortality was observed in treated rats at 5000 mg/kg bw
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
The lethal concentration (LD50) value for acute oral toxicity test was considered to be >5000 mg/kg bw,when rats were treated with 4-(p-methoxyphenyl)butan-2-one (104-20-1) orally.
Executive summary:

Acute oral toxicity study was done in rats using test material 4-(p-methoxyphenyl)butan-2-one (104-20-1) .No mortality was observed at dose 5000 mg/kg bw. Hence,LD50 value was considered to be >5000 mg/kg bw,when rats were treated with 4-(p-methoxyphenyl)butan-2-one (104-20-1)orally.