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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer reviewed journal.

Data source

Reference
Reference Type:
publication
Title:
Fragrance raw materials monographs: 4-(p-methoxyphenyl) butan-2-one
Author:
D. L. J. Opdyke
Year:
1974
Bibliographic source:
Food and Cosmetics Toxicology. 12, 929, 1974

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
48-hr closed patch test was done to evaluate irritation effect of 4-(p-methoxyphenyl) butan-2-one in human subjects.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
IUPAC: 4-(p-methoxyphenyl)butan-2-one
commen name: anisyl acetone
Molecular formula:C11H14O2
Molecular weight : 178.23 g/mole
Substance type: Organic
InChI :1S/C11H14O2/c1-9(12)3-4-10-5-7-11(13-2)8-6-10/h5-8H,3-4H2,1-2H3
Smiles :c1(ccc(OC)cc1)CCC(C)=O
Specific details on test material used for the study:
IUPAC: 4-(p-methoxyphenyl)butan-2-one
commen name: anisyl acetone
Molecular formula:C11H14O2
Molecular weight : 178.23 g/mole
Substance type: Organic
InChI :1S/C11H14O2/c1-9(12)3-4-10-5-7-11(13-2)8-6-10/h5-8H,3-4H2,1-2H3
Smiles :c1(ccc(OC)cc1)CCC(C)=O
physical property: colourless oily liquid

Test animals

Species:
other: human
Strain:
not specified
Details on test animals and environmental conditions:
No data available

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
other: petrolatum
Controls:
not specified
Amount / concentration applied:
5% in petrolatum
Duration of treatment / exposure:
48 hrs
Observation period:
48 hrs
Number of animals:
no data
Details on study design:
no data available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
48 h
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No indication of any skin reaction

Applicant's summary and conclusion

Interpretation of results:
other: Not irritant
Conclusions:
The substance 4-(p-methoxyphenyl) butan-2-one produced no skin reaction when applied on human skin. 4-(p-methoxyphenyl) butan-2-one was considered to be not irritant to human skin
Executive summary:

4-(p-methoxyphenyl) butan-2-one was used as a test material to evaluate its skin irritation potential .

 4-(p-methoxyphenyl) butan-2-one was used in the concentration of 5% in petrolatum for 48hrs in a closed patch test on human subjects.

 The substance 4-(p-methoxyphenyl) butan-2-one produced no skin reaction when applied on human skin.

 4-(p-methoxyphenyl) butan-2-one was considered to be not irritant to human skin.