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EC number: 500-003-1 | CAS number: 9003-13-8
An acute oral toxicity test (Acute Toxic Class Method) was conducted with Fischer 344 rats to determine the potential for Dowanol™ TPnB-H Glycol Ether to produce toxicity from a single dose via the oral route. Under the conditions of this study, the acute oral LD50 of Dowanol™ TPnB-H Glycol Ether is estimated to be between 300 and 2,000 mg/kg of body weight in female rats. An initial dose of 2,000 mg/kg was administered to three healthy female rats by oral gavage. Due to the death of two of these animals, the study proceeded to the next lower dose level. Three females simultaneously received a dose of 300 mg/kg. Since these animals survived, three additional females received a 300 mg/kg dose, simultaneously. Since these animals survived, no additional animals were tested. All animals were observed for mortality, signs of gross toxicity, and behavioral changes at least once daily for 14 days after dosing or until death occurred. Body weights were recorded prior to administration, and on Days 7 and 14 (termination) following dosing. Necropsies were performed on all animals at sacrifice.
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