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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1995
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reference:
Composition 0
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
GLP compliance:
yes
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Test material information:
Composition 1
Specific details on test material used for the study:
- Batch No.: 12054767
- Purity: 100.0 %
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
2.7
Temp.:
25 °C
pH:
7
Remarks on result:
other: 95 % confidence limits 2.50-2.81
Details on results:
This result is in reasonable good agreement with the result of a preliminary test log Pow of 2.47, which is obtained by calculation with the computer program CLOGP (version 3.54 - 5190, Pomona College, Medical Chemistry Project, Claremont, USA). This method is based on the summation of molecular increments to the total log P ow of the substance.
Conclusions:
The partition coefficient (log Pow) was determined to be 2.7 at 25°C and pH 7.
Executive summary:

The n-octanol/water partition coefficient (log Pow)was determined according to EU Testing Guideline A.8 (HPLC method based on OECD guideline No. 117) to be 2.7 (95 % confidence limits 2.50 -2.81) at 25 °C, which indicates no lipophilicity. The method is based on the correlation of the reversed phase retention data of the test compound with those of reference compounds with known log Pow values.

Description of key information

The partition coefficient (log Pow) was determined to be 2.7 at 25°C and pH 7.

Key value for chemical safety assessment

Log Kow (Log Pow):
2.7
at the temperature of:
25 °C

Additional information

There is no classification expected resulting out of the studies concerning the partition coefficient.