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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
other:
Reference:
Composition 0
Conclusions:
Norethisteron does not contain functional groups which are susceptible to hydrolytic degradation. Hydrolytic stability is thus to be expected.
Executive summary:

Norethisteron does not contain functional groups which are susceptible to hydrolytic degradation. Hydrolytic stability is thus to be expected. This notion is experimentally supported by the results of a hydrolysis study with Levonorgestrel (CAS. 797-63 -7) which is structurally similar to Norethisteron.

Description of key information

Norethisterone can be classified as hydrolytically stable at pH 5, 7 and 9 (25 °C).

Key value for chemical safety assessment

Half-life for hydrolysis:
1 yr
at the temperature of:
25 °C

Additional information

"Should read: > 1 year at 25 °C"

Norethisterone does not contain any functional group which is susceptible to hydrolytic degradation. Thus hydrolytic stability is to be expected. This is experimentally supported by the results of a hydrolysis study with Levonorgestrel (CAS 797-63-7), which differs in an ethyl- instead of the methyl group in position 13 and was found to be hydrolytically stable in the pH region 5 to 9 (at 25 °C).The same behaviour is to be expected for norethisterone.