Registration Dossier
Registration Dossier
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EC number: 201-814-0 | CAS number: 88-24-4
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
BCF: 840 at 0.5 µg/L (equivalent to OECD 305)
BCF: 920 at 0.05 µg/L (equivalent to OECD 305)
Key value for chemical safety assessment
- BCF (aquatic species):
- 920 dimensionless
Additional information
One experimental study is available investigating the potential of bioconcentration of 6,6’-di-tert-butyl-4,4’-diethyl-2,2’-methylenediphenol in carp (Kurume, 2012). The study followed “Bioconcentration studies of chemical substances in bodies of fish and shellfish" stipulated in “Testing Methods for New Chemical Substances” (Notification No. 1100331009 of the Ministery of Environment, March 2010) which is equivalent to OECD 305. Cyprinus carpio was exposed to two concentrations of the test substance (0.5 and 0.05 µg/L). The test concentrations were selected based on a preliminary acute toxicity test with Oryzias latipes (LC50 (96 h) > 3.0 mg/L). During 28-d exposure the test concentrations were measured regularly in the test water and in fish to determine the BCF. The measured concentrations were maintained on a constant level throughout the test (flow-through exposure). A lipid content of 3.94% at start of exposure and 4.34% at the end of exposure was recorded.
Changes in bioconcentration factor (mean) after 13, 21, and 28 days were within 1-15% of the mean of the bioconcentration factor from 3 analyses. It was thus deemed that a steady state had been reached. The steady state BCF values were 840 (0.5 µg/L) and 920 (0.05 µg/L).
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