Registration Dossier
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EC number: 212-849-6 | CAS number: 873-69-8
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- adopted 13. April 2004
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Version / remarks:
- 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: SOP 118 009 30 “Bestimmung des log POW (Verteilungskoeffizient n-Octanol/Wasser) mittels HPLC“
- Version / remarks:
- edition 6, adopted 15. Jul. 2013
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Pyridine-2-carbaldehyde oxime
- EC Number:
- 212-849-6
- EC Name:
- Pyridine-2-carbaldehyde oxime
- Cas Number:
- 873-69-8
- Molecular formula:
- C6H6N2O
- IUPAC Name:
- pyridine-2-carbaldehyde oxime
- Test material form:
- solid: particulate/powder
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Key result
- Type:
- log Pow
- Partition coefficient:
- < 0.3
- Temp.:
- 25 °C
- Remarks on result:
- other: only pH value reported was before determination (7.18)
- Details on results:
- Using the correlation log K / log Pow, the log Pow of the test item was calculated as 0.107 ± 0.000. These values are the means ± standard deviations of three independent determinations. As the calculated log Pow of the test item lies below the lowest log Pow of the reference items (2-Butanone with log Pow 0.3), the log Pow of the test item is stated as < 0.3.
Applicant's summary and conclusion
- Conclusions:
- The logPow of the test material has been determined to be < 0.30 at 25 °C. The study was performed according to the OECD TG117 and EU Method A.8 (GLP) without deviations and therefore considered to be of the highest quality (reliability Klimisch 1).The validity criteria are fulfilled.
- Executive summary:
The partition coefficient of the test item was determined in a GLP study according to OECD 117 resp. EU Method A.8. Using the HPLC method, The log Pow of the test item was calculated as 0.107 ± 0.000. These values are the means ± standard deviations of three independent determinations. As the calculated log Pow of the test item lies below the lowest log Pow of the reference items (2-Butanone with log Pow 0.3), the log Pow of the test item is stated as < 0.3. No observations were made which might cause doubts concerning the validity of the study outcome.
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