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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2016-09-05 - 2016-09-22 (experimental phase)
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report date:
2017

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
OECD Guidelines for the Testing of Chemicals, Method No. 104, adopted 23. Mar. 2006: “Vapour Pressure“
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
Council Regulation (EC) No 761/2009 of 24 August 2009, Method A.4: “Vapour Pressure”
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Remarks:
Landesamt für Umwelt, Wasserwirtschaft und Gewerbeaufsicht, Kaiser-Friedrich-Straße 7, 55116 Mainz
Type of method:
effusion method: Knudsen cell

Test material

Constituent 1
Chemical structure
Reference substance name:
Pyridine-2-carbaldehyde oxime
EC Number:
212-849-6
EC Name:
Pyridine-2-carbaldehyde oxime
Cas Number:
873-69-8
Molecular formula:
C6H6N2O
IUPAC Name:
pyridine-2-carbaldehyde oxime
Test material form:
solid: particulate/powder
Specific details on test material used for the study:
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: The test item was stored in a closed vessel at 17.7 – 24.4 °C.

Results and discussion

Vapour pressureopen allclose all
Key result
Temp.:
20 °C
Vapour pressure:
0.02 Pa
Remarks on result:
other: calculated from the regression equation
Key result
Temp.:
25 °C
Vapour pressure:
0.041 Pa
Remarks on result:
other: calculated from the regression equation

Applicant's summary and conclusion

Conclusions:
The study was conducted under GLP according to OECD guideline 104 on the registered substance itself. The method is to be considered scientifically reasonable with no deficiencies in documentation or any deviations, the validity criteria are fulfilled. Hence, the results can be considered as reliable to determine the vapour pressure of the test item.
Executive summary:

The vapour pressure of pyridine-2-carbaldehyde oxime was determined following EU A.4 and OECD 104 under GLP using the effusion method (weight loss).

Vapour pressure was examined at three different temperatures. All temperatures could be evaluated as they showed reproducible weight loss. For these temperatures, 1/T was plotted against log (P).

 

Table Vapour Pressures (Effusion Method)

Experiment

T

Mean P

Stand. Dev. P

RSD P

No.

K

Pa

Pa

%

1

303.2

8.36E-02

4.42E-03

5.3%

2

318.2

5.94E-01

1.49E-02

2.5%

3

333.2

3.51

5.40E-02

1.5%

In this table, E-0X represents multiplication with 10-x.

Stand. Dev. = Standard Deviation; RSD = Relative Standard Deviation

 

The graph 1/T vs. log (P) shows a straight line with a correlation coefficient of - 1.0000.

For the test itempyridine-2-carbaldehyde oxime, the following vapour pressures at 20 °C and at 25 °C were calculated from the regression equation:

Vapour pressure at 20 °C:2.02* 10-02Pa

Vapour pressure at 25 °C:4.14* 10-02Pa