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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Reference
Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from J-check authoritative databases
Qualifier:
according to
Guideline:
OECD Guideline 211 (Daphnia magna Reproduction Test)
Principles of method if other than guideline:
Acute toxic effect on the Daphnia magna was observed by using the chemical alpha-Amyl cinnamaldehyde.

GLP compliance:
not specified
Specific details on test material used for the study:
- Name of test material (as cited in study report): α-Amyl Cinnamaldehyde
- Molecular formula (if other than submission substance): C14H18O
- Molecular weight (if other than submission substance): 202.2952 g/mol
- Substance type: Organic
- Physical state: No data
- Purity: No data
- Impurities (identity and concentrations): No data
Analytical monitoring:
not specified
Details on sampling:
No data
Vehicle:
not specified
Details on test solutions:
No data
Test organisms (species):
Daphnia magna
Details on test organisms:
No data
Test type:
static
Water media type:
freshwater
Total exposure duration:
21 d
Remarks on exposure duration:
No data
Post exposure observation period:
No data
Hardness:
No data
Test temperature:
No data
pH:
No data
Dissolved oxygen:
No data
Salinity:
No data
Conductivity:
No data
Nominal and measured concentrations:
Nominal
Details on test conditions:
No data
Reference substance (positive control):
not specified
Key result
Duration:
21 d
Dose descriptor:
EC50
Effect conc.:
0.054 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
immobilisation
Key result
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
0.041 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
immobilisation
Details on results:
No data
Results with reference substance (positive control):
No data
Reported statistics and error estimates:
No data
Validity criteria fulfilled:
not specified
Conclusions:
Based on the 0.054 mg/l EC50 and 0.041mg/l NOEC value, it can be concluded that the test chemical alpha-Amyl cinnamaldehyde can be considered as toxic to the aquatic organism daphnia at environment revelent concentration and thus can be considered to be classified in aquatic chronic category 2 as per the classification criteria.

Executive summary:

Long term toxic effect on the Daphnia magna was observed by using the chemical alpha-Amyl cinnamaldehyde with the exposure of 21 days. The EC50 value and NOEC concentration obtain from the test was 0.054 mg/l and 0.041 mg/l.

Based on the 0.054 mg/l EC50 and 0.041mg/l NOEC value, it can be concluded that the test chemical alpha-Amyl cinnamaldehyde can be considered as toxic to the aquatic organism daphnia at environment revelent concentration and thus can be considered to be classified in aquatic chronic category 2 as per the CLP classification criteria.    

Description of key information

Long term toxic effect on the Daphnia magna was observed by using the chemical alpha-Amyl cinnamaldehyde with the exposure of 21 days. The EC50 value and NOEC concentration obtain from the test was 0.054 mg/l and 0.041 mg/l.

Based on the 0.054 mg/l EC50 and 0.041mg/l NOEC value, it can be concluded that the test chemical alpha-Amyl cinnamaldehyde can be considered as toxic to the aquatic organism daphnia at environment revelent concentration and thus can be considered to be classified in aquatic chronic category 2 as per the CLP classification criteria.

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater invertebrates:
0.041 mg/L

Additional information

Based on the experimental key study (J-check authoritative databases, 2016) long term toxic effect on the Daphnia magna was observed by using the chemical alpha-Amyl cinnamaldehyde(122 -40 -7) 2 -benzylideneheptanal with the exposure of 21 days. The EC50 value and NOEC concentration obtain from the test was 0.054 mg/l and 0.041 mg/l.Thus on the basis of 0.054 mg/l EC50 and 0.041mg/l NOEC value, it can be concluded that the test chemical alpha-Amyl cinnamaldehyde can be considered as toxic to the aquatic organism daphnia at environment revelent concentration and thus can be considered to be classified in aquatic chronic category 2 as per the CLP classification criteria.