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Ecotoxicological information

Short-term toxicity to fish

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Reference
Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from J-check authoritative databases.
Qualifier:
according to
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Principles of method if other than guideline:
short term toxicity study on the fish of the chemical alpha-Amyl cinnamaldehyde.
GLP compliance:
not specified
Specific details on test material used for the study:
- Name of test material: α-Amyl Cinnamaldehyde
- Molecular formula : C14H18O
- Molecular weight : 202.2952 g/mol
- Substance type: Organic
- Physical state: No data
- Purity: No data
- Impurities: No data
Analytical monitoring:
not specified
Details on sampling:
No data
Vehicle:
not specified
Details on test solutions:
no data
Test organisms (species):
not specified
Details on test organisms:
no data
Test type:
static
Water media type:
freshwater
Total exposure duration:
96 h
Remarks on exposure duration:
no data
Post exposure observation period:
No data
Hardness:
No data
Test temperature:
No data
pH:
No data
Dissolved oxygen:
No data
Salinity:
No data
Conductivity:
No data
Nominal and measured concentrations:
nominal
Details on test conditions:
No data
Reference substance (positive control):
not specified
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
0.91 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Details on results:
No data
Results with reference substance (positive control):
No data
Reported statistics and error estimates:
No data
Validity criteria fulfilled:
not specified
Conclusions:
Based on the mortality of the fish due to alpha-Amyl cinamaldehyde, the LC50 is 0.91mg/l.
Executive summary:

Short term toxic effect on the fish was observed by using the chemical alpha-Amyl cinnamaldehyde, by using the static method with the 96hrs of exposure period. The study was carried out as according to the OECD guideline.

 

Based on the 0.91mg/l LC50 value, it can be concluded that the test chemical alpha-Amyl cinnamaldehyde can be considered as toxic to the aquatic organism fish at environment revelent concentration and thus can be considered to be classified in aquatic acute category 1 as per the CLP classification criteria.

Description of key information

Based on the experimental key study (J-check authoritative databases, 2016) short term toxicity to fish was observed by using the chemical alpha-Amyl cinnamaldehyde(122 -40 -7) 2 -benzylideneheptanal,by using the static method with the 96hrs of exposure period. The study was carried out as according to the OECD guideline.Based on the 0.91mg/l LC50 value, it can be concluded that the test chemical alpha-Amyl cinnamaldehyde can be considered as toxic to the aquatic organism fish at environment revelent concentration and thus can be considered to be classified in aquatic acute category 1 as per the CLP classification criteria.

Key value for chemical safety assessment

LC50 for freshwater fish:
0.91 mg/L

Additional information

Based on the various experimental data and prediction data by using the EPI suite ECOSAR for the target chemical have been reviewed to determine the toxic nature of alpha-Amyl cinnamaldehyde (122-40-7), IUPAC name 2-benzylideneheptanal on the growth of fishes. The studies are as mentioned below:

 

Based on the experimental key study (J-check authoritative databases, 2016) short term toxicity to fish was observed by using the chemical alpha-Amyl cinnamaldehyde (122 -40 -7) 2 -benzylideneheptanal, by using the static method with the 96hrs of exposure period. The study was carried out as according to the OECD guideline. Based on the 0.91mg/l LC50 value, it can be concluded that the test chemical alpha-Amyl cinnamaldehyde can be considered as toxic to the aquatic organism fish at environment revelent concentration and thus can be considered to be classified in aquatic acute category 1 as per the CLP classification criteria.

 

Similarly in another supporting study for alpha amyl cinnamaldeyde (122-40-7), in the RIFM report, 2015 Short term toxic effect on the fish was observed by using the chemical alpha-Amyl cinnamaldehyde, by using the static method with the 96hrs of exposure period. Study performed as per the OECD guideline. Based on the LC100 i.e. 3 mg/l value, it can be concluded that the test chemical alpha-Amyl cinnamaldehyde can be considered as toxic to the aquatic organism fish at environment relevant concentration and thus can be considered to be classified in aquatic chronic category 2 as per the CLP classification criteria.

 

In another supporting study for target chemical (FFHPVC), 2005 Short term toxicity effect on the zebrafish was observed by using the chemical alpha-Amyl cinnamaldehyde. Study performed by using semi static method with the 96hrs of exposure period. Based on the 3.14 mg/l value, it can be concluded that the test chemical alpha-Amyl cinnamaldehyde can be considered as toxic to the aquatic organism fish at environment relevant concentration and thus can be considered to be classified in aquatic chronic category 2 as per the CLP classification criteria.

 

Based on the prediction done by EPI suite, ECOSAR version 1.1, for alpha-Amyl cinnamaldehyde (122-40-7) on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the LC 50 value for short term toxicity to fish was predicted. On the basis of EPI suite, ECOSAR version 1.1, the LC 50 value for short term toxicity to fish was predicted to be 1.344 mg/l for CAS name alpha amyl cinnamaldehyde in 96 hrs. Based on this value it can be concluded that the substance is considered to be toxic to aquatic environment and can be classified in aquatic chronic 2 category as per the criteria mentioned in CLP regulation.

 

The experimental key study classify the chemical in acute category 1, but remaining studies support chronic category 2. As the small amount of chemical was toxic to the growth of fishes thus by considering the key study alpha-Amyl cinnamaldehyde classified in acute 1 category.

 

Based on the data available for the target chemical alpha-Amyl cinnamaldehyde (122-40-7), IUPAC name 2-benzylideneheptanal from various databases and prediction models, alpha-Amylcinnamaldehyde exhibit toxicity on the growth of fishes. Hence the test chemical is likely to classify as toxic and consider acute 1 as per the criteria mentioned in CLP regulation.